Evidence map›Paper›PMID 36346461›Full record

ArticleJournal of the American Chemical Society2022

General Synthetic Approach to Diverse Taxane Cores.

Melecio A Perea, Brian Wang, Benjamin C Wyler, Jin Su Ham, Nicholas R O'Connor, Shota Nagasawa, Yuto Kimura, Carolin Manske, Maximilian Scherübl, Johny M Nguyen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Gram-Scale Access to (3,11)-Cyclotaxanes-Synthesis of 1-Hydroxytaxuspine C.Angewandte Chemie (International ed. in English) · 2025
    Article
  2. Skeletal Editing Strategies Driven by Total Synthesis.Accounts of chemical research · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Practical and General Alcohol Deoxygenation Protocol.Angewandte Chemie (International ed. in English) · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melecio A PereaDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Brian WangDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Benjamin C WylerDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Jin Su HamDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Nicholas R O'ConnorDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Shota NagasawaDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Yuto KimuraDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Carolin ManskeDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Maximilian ScherüblDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Johny M NguyenDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Richmond SarpongDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-0028-6323

Funding

Proposal for Central California 900 MHZ NMR SpectrometerP41GM068933 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI WEMMER, DAVID E · 2003 to 2007
$5.9M
Strategies and Methods for Complex Molecule Synthesis: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer ConsoleR35GM130345 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Richmond Sarpong · 2019 to 2026
$5.4M
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
Synthesis and study of oxo-bridged taxanes by C-C activation/cross-coupling of carvone-derived cyclobutanolsF32GM123601 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI O'CONNOR, NICHOLAS RYAN · 2017 to 2019
$77k
Total Synthesis of Oxo-Bridged Taxoids and Evaluation of their Anticancer PropertiesF31GM139368 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI PEREA, MELECIO · 2020 to 2021
$77k
NIGMS NIH HHS F31 GM139368NIGMS NIH HHS F32 GM123601NIGMS NIH HHS P41 GM068933NIGMS NIH HHS R35 GM130345NIH HHS S10 OD024998
6 · The paper itself

Abstract

Chemical synthesis of natural products is typically inspired by the structure and function of a target molecule. When both factors are of interest, such as in the case of taxane diterpenoids, a synthesis can both serve as a platform for synthetic strategy development and enable new biological exploration. Guided by this paradigm, we present here a unified enantiospecific approach to diverse taxane cores from the feedstock monoterpenoid (

Indexed as

MonoterpenesTaxoidsBridged-Ring CompoundsCyclohexane MonoterpenesStereoisomerismBridged-Ring CompoundscarvoneCyclohexane MonoterpenesMonoterpenestaxaneTaxoids

Identifiers

PMID36346461
PMCPMC9901290

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.