Evidence map›Paper›PMID 36346452›Full record

ArticleThe Journal of infectious diseases2022

Multiple Infection and Human Immunodeficiency Virus Superinfection Among Persons who Inject Drugs in Indonesia and Ukraine.

Philip J Palumbo, Wendy Grant-McAuley, Mary Kate Grabowski, Yinfeng Zhang, Paul Richardson, Estelle Piwowar-Manning, Deeksha Sharma, William Clarke, Oliver Laeyendecker, Scott Rose and 8 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 3 countries.

Philip J PalumboDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wendy Grant-McAuleyDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mary Kate GrabowskiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yinfeng ZhangDivision of Molecular & Genomic Pathology, University of Pittsburgh Medical Center Presbyterian Shadyside, Pittsburgh, Pennsylvania, USA.
Paul RichardsonDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Estelle Piwowar-ManningDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Deeksha SharmaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
William ClarkeDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Oliver LaeyendeckerDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA.
Scott RoseScience Facilitation Department, FHI 360, Durham, North Carolina, USA.
Tran V HaDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kostyantyn DumchevUkrainian Institute on Public Health Policy, Kyiv, Ukraine.
Zubairi DjoerbanDepartments of Hematology, Medical Oncology, and Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Andrew ReddDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA.
Brett HanscomFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Irving HoffmanDepartment of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
William C MillerDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, USA.
Susan H EshlemanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USFred Hutch Cancer Center · USJohns Hopkins Medicine · USUniversity of North Carolina at Chapel Hill · USFamily Health International 360 · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo · IDThe Ohio State University · USUkrainian Institute of Public Health Policy · UAUPMC Presbyterian · US

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619NICHD NIH HHS UM1AI068619-15NIDA NIH HHSNIH HHSNIMH NIH HHS
6 · The paper itself

Abstract

backgroundThe HIV Prevention Trials Network (HPTN) 074 study evaluated an integrated human immunodeficiency virus (HIV) treatment and prevention strategy among persons who inject drugs (PWID) in Indonesia, Ukraine, and Vietnam. We previously detected multiple HIV infection in 3 of 7 (43%) of seroconverters with 3-8 HIV strains per person. In this report, we analyzed multiple HIV infection and HIV superinfection (SI) in the HPTN 074 cohort.

methodsWe analyzed samples from 70 participants in Indonesia and Ukraine who had viral load >400 copies/mL at enrollment and the final study visit (median follow-up, 2.5 years). HIV was characterized with Sanger sequencing, next-generation sequencing, and phylogenetic analysis. Additional methods were used to characterize a rare case of triple-variant SI.

resultsAt enrollment, multiple infection was detected in only 3 of 58 (5.2%) participants with env sequence data. SI was detected in only 1 of 70 participants over 172.3 person-years of follow-up (SI incidence, 0.58/100 person-years [95% confidence interval, .015-3.2]). The SI case involved acquisition of 3 HIV strains with rapid selection of a strain with a single pol region cluster.

conclusionsThese data from a large cohort of PWID suggest that intrahost viral selection and other factors may lead to underestimation of the frequency of multiple HIV infection and SI events.

Indexed as

Drug UsersHIV InfectionsSubstance Abuse, IntravenousSuperinfectionHIVHumansIndonesiaPhylogenyUkraineHIVHPTN 074Indonesiamultiple infectionpersons who inject drugsphylogenetic analysissuperinfectionUkraine

Identifiers

PMID36346452
PMCPMC10205628
OpenAlexW4308528203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.