Evidence map›Paper›PMID 36346228›Full record

ArticlemBio2022

Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry.

Yoshio Mori, Masafumi Sakata, Shota Sakai, Toru Okamoto, Yuichiro Nakatsu, Shuhei Taguwa, Noriyuki Otsuki, Yusuke Maeda, Kentaro Hanada, Yoshiharu Matsuura and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The Implication of Sphingolipids in Viral Infections.International journal of molecular sciences · 2023
    Review
  4. SiScience · 2023
    Article
  5. Review
  6. HIV and SIV Envelope Glycoproteins Interact with Glycolipids and Lipids.International journal of molecular sciences · 2023
    Article
  7. Dissecting Rubella Placental Infection in an In Vitro Trophoblast Model.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yoshio MoriDepartment of Virology, National Institute of Infectious Diseasesgrid.410795.e, Musashimurayama, Tokyo, Japan.ORCID 0000-0001-9441-9117
Masafumi SakataDepartment of Virology, National Institute of Infectious Diseasesgrid.410795.e, Musashimurayama, Tokyo, Japan.
Shota SakaiDepartment of Biochemistry and Cell Biology, National Institute of Infectious Diseasesgrid.410795.e, Shinjuku, Tokyo, Japan.
Toru OkamotoInstitute for Advanced Co-Creation Studies, Osaka Universitygrid.136593.b, Suita, Osaka, Japan.
Yuichiro NakatsuDepartment of Virology, National Institute of Infectious Diseasesgrid.410795.e, Musashimurayama, Tokyo, Japan.
Shuhei TaguwaCenter for Infectious Disease Education and Research, Osaka Universitygrid.136593.b, Suita, Osaka, Japan.
Noriyuki OtsukiDepartment of Virology, National Institute of Infectious Diseasesgrid.410795.e, Musashimurayama, Tokyo, Japan.
Yusuke MaedaLaboratory of Viral Dynamism Research, Research Institute for Microbial Diseases, Osaka Universitygrid.136593.b, Suita, Osaka, Japan.
Kentaro HanadaDepartment of Biochemistry and Cell Biology, National Institute of Infectious Diseasesgrid.410795.e, Shinjuku, Tokyo, Japan.
Yoshiharu MatsuuraCenter for Infectious Disease Education and Research, Osaka Universitygrid.136593.b, Suita, Osaka, Japan.
Makoto TakedaDepartment of Virology, National Institute of Infectious Diseasesgrid.410795.e, Musashimurayama, Tokyo, Japan.ORCID 0000-0002-8194-7727
National Institute of Infectious Diseases · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lipid composition of the host cell membrane is one of the key determinants of the entry of enveloped viruses into cells. To elucidate the detailed mechanisms behind the cell entry of rubella virus (RuV), one of the enveloped viruses, we searched for host factors involved in such entry by using CRISPR/Cas9 genome-wide knockout screening, and we found sphingomyelin synthase 1 (SMS1), encoded by the

Indexed as

RubellaRubella virusCell MembraneCytoplasmFemaleHumansNucleocapsidPregnancySphingomyelinsViral Envelope ProteinsVirionVirus InternalizationSphingomyelinsViral Envelope ProteinsCRISPR/Cas9fusionhemifusionmembrane fusionrubella virussphingomyelin

Identifiers

PMID36346228
PMCPMC9765692
OpenAlexW4308507720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.