Evidence map›Paper›PMID 36346220›Full record

ArticleeLife2022

Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in

Justin A Bosch, Berrak Ugur, Israel Pichardo-Casas, Jordan Rabasco, Felipe Escobedo, Zhongyuan Zuo, Ben Brown, Susan Celniker, David A Sinclair, Hugo J Bellen and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Sketching microprotein portraits.Protein science : a publication of the Protein Society · 2026
    Review
  2. Article
  3. Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Justin A BoschDepartment of Genetics, Blavatnick Institute, Harvard Medical School, Boston, United States.ORCID 0000-0001-8499-1566
Berrak UgurDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-4806-8891
Israel Pichardo-CasasDepartment of Genetics, Blavatnick Institute, Harvard Medical School, Boston, United States.
Jordan RabascoDepartment of Genetics, Blavatnick Institute, Harvard Medical School, Boston, United States.
Felipe EscobedoDepartment of Genetics, Blavatnick Institute, Harvard Medical School, Boston, United States.ORCID 0000-0002-6830-9210
Zhongyuan ZuoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Ben BrownLawrence Berkeley National Laboratory, Berkeley, United States.
Susan CelnikerLawrence Berkeley National Laboratory, Berkeley, United States.
David A SinclairDepartment of Genetics, Blavatnick Institute, Harvard Medical School, Boston, United States.
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-5992-5989
Norbert PerrimonDepartment of Genetics, Blavatnick Institute, Harvard Medical School, Boston, United States.ORCID 0000-0001-7542-472X
Harvard University · USBaylor College of Medicine · USHoward Hughes Medical Institute · USLawrence Berkeley National Laboratory · US

Funding

New collections of dsRNAs and overexpression miRNA constructs to supplement RNAiR01GM067761 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI PERRIMON, NORBERT · 2003 to 2019
$15.5M
TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
Systematic, Genome-Scale Functional Characterization of Conserved smORFsR01HG009352 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CELNIKER, SUSAN E · 2017 to 2019
$3.0M
Next-generation Drosophila cell lines to elucidate the cellular basis of human diseasesR24OD019847 · OD · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT, SIMCOX, AMANDA · 2017 to 2020
$2.7M
Using CRISPR technology to study the function of paralogous genesR24OD026435 · OD · HARVARD MEDICAL SCHOOL · PI BELLEN, HUGO J, PERRIMON, NORBERT · 2018 to 2021
$2.5M
Howard Hughes Medical InstituteNHGRI NIH HHS R01 HG009352NIGMS NIH HHS R01 GM067761NIGMS NIH HHS R01 GM084947NIGMS NIH HHS T32 GM007748NIH HHS R24 OD019847NIH HHS R24 OD026435
6 · The paper itself

Abstract

Naturally produced peptides (<100 amino acids) are important regulators of physiology, development, and metabolism. Recent studies have predicted that thousands of peptides may be translated from transcripts containing small open-reading frames (smORFs). Here, we describe two peptides in

Indexed as

DrosophilaElectron Transport Complex IIIAnimalsNeuronsOpen Reading FramesPeptidesElectron Transport Complex IIIPeptidesCRISPR/Cas9D. melanogastergeneticsgenomicsmitochondrianeurodegenerationneuroscienceparalogspeptidesmORF

Identifiers

PMID36346220
PMCPMC9681215
OpenAlexW4308555011

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.