Evidence map›Paper›PMID 36346203›Full record

ArticleHuman brain mapping2023

Hippocampus shape characterization with 3D Zernike transformation in clinical Alzheimer's disease progression.

David C Zhu, Chih-Ying Gwo, An-Wen Deng, Norman Scheel, Mari A Dowling, Rong Zhang, Alzheimer's Disease Neuroimaging Initiative

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

David C ZhuDepartment of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-5264-0144
Chih-Ying GwoDepartment of Information Management, Chien Hsin University of Science and Technology, Taoyuan City, Taiwan.ORCID 0000-0002-0678-1966
An-Wen DengDepartment of Information Management, Chien Hsin University of Science and Technology, Taoyuan City, Taiwan.
Norman ScheelDepartment of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, Michigan, USA.
Mari A DowlingDepartment of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, Michigan, USA.
Rong ZhangDepartments of Neurology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Alzheimer's Disease Neuroimaging Initiative
Michigan State University · USChien Hsin University of Science and Technology · TWTexas Health Dallas · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Hypertension, intracranial pulsatility and brain A-beta accumulation in older adultsR01AG057571 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI VONGPATANASIN, WANPEN, ZHANG, RONG · 2017 to 2021
$3.6M
NIA NIH HHS R01 AG057571NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of dementia among older adults. Mild cognitive impairment (MCI) is considered a transitional phase between healthy cognitive aging and dementia. Progressive brain volume reduction/atrophy, particularly of the hippocampus, is associated with the transition from normal to MCI, and then to AD. We aimed to develop methods to characterize the shape of hippocampus and explore its potential as an imaging marker to monitor clinical AD progression. We implemented a 3D Zernike transformation to characterize the shape changes of hippocampus in 428 older subjects with high-quality T

Indexed as

Alzheimer DiseaseCognitive DysfunctionNeurodegenerative DiseasesAgedAtrophyDisease ProgressionHippocampusHumansMagnetic Resonance ImagingNeuroimagingAlzheimer's diseasehippocampusshapeZernike transformation

Identifiers

PMID36346203
PMCPMC9921247
OpenAlexW4308552256

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.