Evidence map›Paper›PMID 36345826›Full record

ArticleCirculation research2022

Spatiotemporal Control of Vascular Ca

Miguel Martín-Aragón Baudel, Victor A Flores-Tamez, Junyoung Hong, Gopyreddy R Reddy, Pauline Maillard, Abby E Burns, Kwun Nok Mimi Man, Kent C Sasse, Sean M Ward, William A Catterall and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. CaThe Journal of physiology · 2026
    Article
  3. Article
  4. Aging Disrupts L-type CaCirculation research · 2026
    Article
  5. Review
  6. Context-Dependent Control: PKA Regulation of Vascular CaArteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  7. Article
  8. Article
  9. Amyloid β alters vascular CaThe Journal of physiology · 2025
    Article
  10. Nanoscale architecture and dynamics of CaJournal of molecular and cellular cardiology plus · 2025
    Article
  11. Article
  12. CaInflammation and regeneration · 2025
    Review
  13. 14-3-3 promotes sarcolemmal expression of cardiac CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. α1Journal of the American Heart Association · 2024
    Article
  15. Vascular Function and Ion Channels in Alzheimer's Disease.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  16. Review
  17. Aberrant splicing of CaCellular and molecular life sciences : CMLS · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Miguel Martín-Aragón BaudelDepartment of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).ORCID 0000-0001-9399-4013
Victor A Flores-TamezDepartment of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).ORCID 0000-0001-8369-9192
Junyoung HongDepartment of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).
Gopyreddy R ReddyDepartment of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).
Pauline MaillardDepartment of Neurology, University of California Davis, Davis, CA (P.M.).
Abby E BurnsDepartment of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).
Kwun Nok Mimi ManDepartment of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).ORCID 0000-0002-0132-9129
Kent C SasseSasse Surgical Associates, Reno, NV (K.C.S.).
Sean M WardDepartment of Physiology and Cell Biology, University of Nevada Reno, Reno, NV (S.M.W.).
William A CatterallDepartment of Pharmacology, University of Washington, Seattle, WA (W.A.C.).
Donald M BersDepartment of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).ORCID 0000-0002-2237-9483
Johannes W HellDepartment of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).
Madeline Nieves-Cintrón *Department of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).ORCID 0000-0003-1935-8400
Manuel F Navedo *Department of Pharmacology, University of California Davis, Davis, CA (M.M.-A.B., V.A.F.-T., J.H., G.R.R., A.E.B., K.N.M.M., D.M.B., J.W.H., M.N.-C., M.F.N.).ORCID 0000-0001-6864-6594
MACOM (United States) · USUniversity of California, Davis · USUniversity of Nevada, Reno · USUniversity of Washington · USUniversity Surgical Associates · US

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Structural Basis for Antiarrhythmic Drug ActionR01HL112808 · NHLBI · UNIVERSITY OF WASHINGTON · PI ZHENG, NING · 2012 to 2025
$7.8M
Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Role of a-actinin in Cav1.2 FunctionR01AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2016 to 2026
$4.0M
cAMP signaling in vascular smooth muscle in health and diseaseR01HL161872 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2022 to 2025
$2.6M
Postsynaptic Signaling by Norepinephrine and cAMPR01NS123050 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2022 to 2026
$2.3M
NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL112808NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01 HL161872NIA NIH HHS R01 AG055357NINDS NIH HHS R01 NS123050
6 · The paper itself

Abstract

backgroundL-type Ca

methodsA multiscale approach including patch-clamp electrophysiology, super-resolution nanoscopy, proximity ligation assay, calcium imaging' pressure myography, and Laser Speckle imaging was implemented to examine Ca

resultsCa

conclusionsThese results suggest that PKA-dependent S1928 phosphorylation promotes the spatial reorganization of vascular α1

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2HyperglycemiaAnimalsCalcium Channels, L-TypeHumansMiceMuscle, Smooth, VascularPhosphorylationCalcium Channels, L-Typeclusteringcooperative gatingdiabeteshyperglycemiavascular dysfunction

Identifiers

PMID36345826
PMCPMC9722584
OpenAlexW4308555810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.