Trial reportJournal of clinical periodontology2023
Influence of healing time on the outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft: A randomized clinical trial.
Trial report in Journal of clinical periodontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical, Radiographic and Histomorphotmetric Analysis of Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®: A Prospective 3-year Post-loading Study
Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets: a Randomized Controlled Trial
Use of OsteoBiol® Lamina® Soft and Different Collagen-based Graft Materials in Bone Regeneration: A Pilot Prospective Controlled Clinical Trial
Biomaterials Exposed to Oral Environment: Which One is the Appropriate Option?
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta-analyses.Periodontology 2000 · 2025Pooled it
- The effect of bioactive membrane in alveolar ridge preservation: A double-blind randomized clinical trial.Journal of periodontology · 2026Trial
- De-epithelialized gingival unit graft for gingival phenotype modification and root coverage: a randomized controlled trial.Clinical oral investigations · 2026Trial
- Outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft: A randomized controlled trial.Journal of periodontology · 2026Trial
- Timing of Re-Evaluation After Periodontal Therapy: A Randomized Clinical Trial.Journal of periodontal research · 2026Trial
- Plasma rich in growth factors in alveolar ridge preservation: randomized, controlled clinical trial.Clinical oral investigations · 2026Trial
- Laser-assisted socket seal surgery using bioactive glass for dental implant site development: a randomized clinical trial.Scientific reports · 2025Trial
- Dimensional Changes After Different Alveolar Ridge Preservation Techniques for Posterior Region: A Randomised Controlled Clinical Trial.Journal of clinical periodontology · 2025Trial
- Influence of healing time on the outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft: A randomized clinical trial.Journal of clinical periodontology · 2023Trial
- Histological and radiographic evaluation of bone formation following alveolar ridge preservation using octacalcium phosphate collagen composite: A prospective non-randomized controlled clinical trial.Clinical oral investigations · 2026Article
- Volumetric Analysis of Ridge Preservation Using Bio-OssMedicina (Kaunas, Lithuania) · 2026Article
- Assessment of collagen hemostatic membrane and sponge in alveolar sockets: A quasi-experimental prospective clinical study.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Effect of Alveolar Process and Basal Bone Features on Post-Extraction Dimensional Changes.Journal of clinical periodontology · 2026Article
- Profilometric and radiographic analyses after early implant placement in sites with ridge preservation or spontaneous healing: 3-year follow-up of an exploratory randomized controlled trial.Journal of periodontal & implant science · 2026Article
- Comparative Evaluation of the Effectiveness of Demineralized Freeze-Dried Bone Allografts With Titanium Platelet-Rich Fibrin and Autologous Dentin Graft With Titanium Platelet-Rich Fibrin for Alveolar Socket Preservation: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Comparison of four bone substitute types in sinus augmentation with perforated Schneiderian membrane: An experimental study.Journal of periodontology · 2025Article
- Clinical and Radiological Evaluation of Flap and Flapless Procedures with Biomaterials in Alveolar Ridge Preservation.Journal of functional biomaterials · 2025Article
- A Histological and Clinical Evaluation of Long-Term Outcomes of Bovine Bone-Derived Xenografts in Oral Surgery: A Systematic Review.Journal of functional biomaterials · 2025Review
- The effect of flap advancement on bone graft displacement with or without membrane stabilization - a preclinical study.BMC oral health · 2025Article
- Estimating Molar Root Volume from Panoramic Radiographs Using a Geometric Approach-An Experimental Method Comparison.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the healing outcomes in non-molar post-extraction sockets filled with deproteinized bovine bone mineral with collagen (DBBM-C) as a function of time. MATERIALS AND
methodsPatients in need of non-molar tooth extraction were randomly allocated into one of three groups according to the total healing time (A-3 months; B-6 months; C-9 months). The effect of alveolar ridge preservation (ARP) therapy via socket filling using DBBM-C and socket sealing with a porcine collagen matrix (CM) was assessed based on a panel of clinical, digital, histomorphometric, implant-related, and patient-reported outcomes.
resultsA total of 42 patients completed the study (n = 14 in each group). Histomorphometric analysis of bone core biopsies obtained at the time of implant placement showed a continuous increase in the proportion of mineralized tissue with respect to non-mineralized tissue, and a decrease in the proportion of remaining xenograft material over time. All volumetric bone and soft tissue contour assessments revealed a dimensional reduction of the alveolar ridge overtime affecting mainly the facial aspect. Linear regression analyses indicated that baseline buccal bone thickness is a strong predictor of bone and soft tissue modelling. Ancillary bone augmentation at the time of implant placement was needed in 16.7% of the sites (A:2; B:1; C:4). Patient-reported discomfort and wound healing index scores progressively decreased over time and was similar across groups.
conclusionsHealing time influences the proportion of tissue compartments in non-molar post-extraction sites filled with DBBM-C and sealed with a CM. A variable degree of alveolar ridge atrophy, affecting mainly the facial aspect, occurs even after performing ARP therapy. These changes are more pronounced in sites exhibiting thin facial bone (≤1 mm) at baseline (Clinicaltrials.gov NCT03659617).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.