ArticleeLife2022
The role of adolescent lifestyle habits in biological aging: A prospective twin study.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Pooled it
- Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions.Aging cell · 2026Article
- Changes in Dietary Patterns and Environmental Footprints Among University Students: A Retrospective Study.International journal of environmental research and public health · 2026Article
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Silent losses: predictors of anaemia and micronutrient deficiencies and their associations with menstrual bleeding in Lebanon - findings from a national cross-sectional study.BMJ global health · 2025Article
- Multi-Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences.Aging cell · 2025Article
- Perinatal Exposure to Lead or Diethylhexyl Phthalate in Mice: Sex-Specific Effects on Cardiac DNA Methylation and Gene Expression across Time.Environmental health perspectives · 2025Article
- Genetic and environmental contributions to epigenetic aging across adolescence and young adulthood.Clinical epigenetics · 2025Article
- Social disadvantage accelerates aging.Nature medicine · 2025Article
- A proteomic signature of healthspan.medRxiv : the preprint server for health sciences · 2025Article
- Eating and lifestyle habits associated with regular soft drinks consumption among Brazilian adolescents: National Survey of School Health, 2019.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025Article
- The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality - a prospective twin study.European journal of epidemiology · 2025Article
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Association of marital status with DNA methylation-based biological age among US older adults.Frontiers in public health · 2025Article
- Development of the oral, mental, and sexual reproductive health assessment tool for adolescents in Nigeria.Frontiers in oral health · 2025Article
- Genetic Liability to Cardiovascular Disease, Physical Activity, and Mortality: Findings from the Finnish Twin Cohort.Medicine and science in sports and exercise · 2024Article
- Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.Scientific reports · 2024Article
- Young users of electronic cigarettes exhibit reduced cardiorespiratory fitness.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The Transition from Childhood to Adolescence: Between Health and Vulnerability.Children (Basel, Switzerland) · 2024Review
- Tomorrow Never Comes: The Risks of Procrastination for Adolescent Health.European journal of investigation in health, psychology and education · 2024Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Adolescence is a stage of fast growth and development. Exposures during puberty can have long-term effects on health in later life. This study aims to investigate the role of adolescent lifestyle in biological aging. Methods: The study participants originated from the longitudinal FinnTwin12 study (n = 5114). Adolescent lifestyle-related factors, including body mass index (BMI), leisure-time physical activity, smoking, and alcohol use, were based on self-reports and measured at ages 12, 14, and 17 years. For a subsample, blood-based DNA methylation (DNAm) was used to assess biological aging with six epigenetic aging measures in young adulthood (21-25 years, n = 824). A latent class analysis was conducted to identify patterns of lifestyle behaviors in adolescence, and differences between the subgroups in later biological aging were studied. Genetic and environmental influences on biological aging shared with lifestyle behavior patterns were estimated using quantitative genetic modeling. Results: We identified five subgroups of participants with different adolescent lifestyle behavior patterns. When DNAm GrimAge, DunedinPoAm, and DunedinPACE estimators were used, the class with the unhealthiest lifestyle and the class of participants with high BMI were biologically older than the classes with healthier lifestyle habits. The differences in lifestyle-related factors were maintained into young adulthood. Most of the variation in biological aging shared with adolescent lifestyle was explained by common genetic factors. Conclusions: These findings suggest that an unhealthy lifestyle during pubertal years is associated with accelerated biological aging in young adulthood. Genetic pleiotropy may largely explain the observed associations. Funding: This work was supported by the Academy of Finland (213506, 265240, 263278, 312073 to J.K., 297908 to M.O. and 341750, 346509 to E.S.), EC FP5 GenomEUtwin (J.K.), National Institutes of Health/National Heart, Lung, and Blood Institute (grant HL104125), EC MC ITN Project EPITRAIN (J.K. and M.O.), the University of Helsinki Research Funds (M.O.), Sigrid Juselius Foundation (J.K. and M.O.), Yrjö Jahnsson Foundation (6868), Juho Vainio Foundation (E.S.) and Päivikki and Sakari Sohlberg foundation (E.S.).
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