Evidence map›Paper›PMID 36345679›Full record

ArticleBirth defects research2022

Prevalence of congenital heart defects in Europe, 2008-2015: A registry-based study.

Chrysovalanto Mamasoula, Marie-Claude Addor, Clara Cavero Carbonell, Carlos M Dias, Luis-Javier Echevarría-González-de-Garibay, Miriam Gatt, Babak Khoshnood, Kari Klungsoyr, Kay Randall, Sylvia Stoianova and 18 more

Open access · bronzeAbstract read
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In one paragraph

Article in Birth defects research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Prenatal diagnosis and clinical pregnancy outcome of fetuses with conotruncal defects in a Chinese cohort.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  6. Congenital heart diseases - the forgotten country cousins?Indian journal of thoracic and cardiovascular surgery · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Spatial analysis of risk areas of congenital anomalies in Brazil, 2012-2021.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 17 countries.

Chrysovalanto MamasoulaPopulation Health Sciences Institute, Newcastle University, Newcastle, UK.
Marie-Claude AddorDepartment of Woman-Mother-Child, University Medical Center CHUV, Lausanne, Switzerland.
Clara Cavero CarbonellRare Diseases Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Valencia, Spain.
Carlos M DiasEpidemiology Department, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal.
Luis-Javier Echevarría-González-de-GaribayDirectorate for Healthcare Planning, Organisation and Evaluation; Registries and Health Information Unit, Ministry of Health of the Basque Government, Vitoria-Gasteiz, Spain.
Miriam GattMalta Congenital Anomalies Register, Directorate for Health Information and Research, Pietà, Malta.
Babak KhoshnoodINSERM U1153, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team (EPOPé), Université de Paris, Paris, France.
Kari KlungsoyrDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Kay RandallNational Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Sylvia StoianovaSouth West Congenital Anomaly Register (SWCAR), Bristol Medical School, University of Bristol, Bristol, UK.
Martin HaeuslerStyrian Malformation Registry, Medical University of Graz, Graz, Austria.
Vera NelenProvinciaal Instituut voor Hygiene (PIH), Antwerp, Belgium.
Amanda J NevilleRegistro IMER - IMER Registry (Emilia Romagna Registry of Birth Defects), Center for Clinical and Epidemiological Research, University of Ferrara, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy.
Isabelle PerthusAuvergne Registry of Congenital Anomalies (CEMC-Auvergne), Department of Clinical Genetics, Centre de Référence des Maladies Rares, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.
Anna PieriniTuscany Registry of Congenital Defects (RTDC), Institute of Clinical Physiology - National Research Council/Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Bénédicte Bertaut-NativelRegister of Congenital Malformations of Reunion Island, CHU Réunion, St Pierre, France.
Anke RissmannMalformation Monitoring Centre Saxony-Anhalt, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.ORCID 0000-0002-9437-2790
Florence RougetBrittany Registry of Congenital Anomalies, CHU Rennes, University Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement Ettravail), Rennes, France.
Bruno SchaubFrench West Indies Registry, Registre des Malformations des Antilles (REMALAN), Maison de la Femme de la Mère et de l'Enfant, University Hospital of Martinique, Fort-de-France, France.
David TuckerCARIS, Public Health Wales, Singleton Hospital, Swansea, UK.
Diana WellesleyWessex Clinical Genetics Department, Princess Anne Hospital, Southampton, UK.
Natalya Zymak-ZakutniaOMNI-Net Ukraine Birth Defects Program, Khmelnytsky City Children's Hospital, Khmelnytsky, Ukraine.
Ingeborg BarisicCentre of Excellence for Reproductive and Regenerative Medicine, Children's Hospital Zagreb, Medical School University of Zagreb, Zagreb, Croatia.
Hermien E K de WalleDepartment of Genetics, EUROCAT Northern Netherlands, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Monica LanzoniEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Carmel MullaneyDepartment of Public Health, Health Service Executive (HSE) South East Area, Dublin, Ireland.
Lindsay PenningtonPopulation Health Sciences Institute, Newcastle University, Newcastle, UK.
Judith RankinPopulation Health Sciences Institute, Newcastle University, Newcastle, UK.
Newcastle University · GBInserm · FRBasque Government · ESCentre Hospitalier Universitaire de Clermont-Ferrand · FRCentre Hospitalier Universitaire de Martinique · MQFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESHealth Service Executive · IEIstituto di Fisiologia Clinica · ITJoint Research Centre · ITKhmelnytskyi National University · UAMedical University of Graz · ATMinistry for Health · MTMother Hospital · INNational Institute of Health Dr. Ricardo Jorge · PTNorwegian Institute of Public Health · NOOtto-von-Guericke-Universität Magdeburg · DEPrincess Anne Hospital · GBProvincial Institute for Hygiene · BESingleton Hospital · GBUniversity Hospital Centre Zagreb · HR

Funding

Medical Research Council MR/K02325X/1
6 · The paper itself

Abstract

backgroundThe total prevalence of congenital heart defects (CHDs) varies by populations and over time. Studies that examine trends in the prevalence of CHD in different regions may shed light on our understanding of the occurrence of CHD and the impact of different risk factors.

objectivesTo examine trends in total and live birth prevalence of nonsyndromic CHD in Europe between the years 2008 and 2015 and to investigate if the decreasing trend reported by previous studies is continuing.

methodsCases of CHD delivered between January 1, 2008 and December 31, 2015 notified to 25 population-based EUROCAT (European Surveillance of Congenital Anomalies) registries in 14 countries, formed the population-based case-series. Prevalence (total/live) rates and 95% confidence intervals were calculated as the number of cases per 10,000 births (live and stillbirths). Time trends in prevalence of all nonsyndromic CHDs and for three CHD severity groups (very severe, severe, and less severe) were plotted using a Poisson regression multilevel approach.

resultsThe total prevalence of nonsyndromic CHD was 57.1 per 10,000 births (live births and stillbirths) for the 8-year period and remained stable across the three CHD severity groups while the live birth prevalence was 60.2 per 10,000 births. There was considerable variation in the reported total CHD prevalence and the direction of trends by registry. A decreasing prevalence of CHD was observed for the Norway and England/Wales registries, whereas the CHD prevalence increased for registries in Italy and Croatia.

conclusionsThe total prevalence of CHD in Europe between the years 2008 and 2015 remained stable for all CHD and across the three CHD severity groups. The decreasing trend reported by previous studies has not continued. However, we found significant differences in the total and live birth prevalence by registry.

Indexed as

Heart Defects, CongenitalStillbirthEuropeFemaleHumansPregnancyPrevalenceRegistriescongenital heart diseaseEuropean Surveillance of Congenital Anomaliesprevalence rate

Identifiers

PMID36345679
PMCPMC10098845
OpenAlexW4308550317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.