ArticleMaterials today. Bio2022
Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues.
Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
- Covalent grafting of hyaluronic acid on drug nanocrystals for mucosal delivery.Journal of materials chemistry. B · 2026Article
- An AI-assisted designed supramolecularly engineered nanoplatform reverses pigmentation by triggering an ineffective compensatory melanin production program.Bioactive materials · 2026Article
- Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitis.Drug delivery and translational research · 2026Article
- Tailoring PLA/Gelatin Film Properties for Food Packaging Using Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2025Article
- Eutectogels: Recent Advances, Design Strategies, and Emerging Applications in Biotechnology.Gels (Basel, Switzerland) · 2025Review
- Deep Eutectic Solvents in Polymeric Drug Carriers: Insights into Release Behavior and Functional Integration.ChemistryOpen · 2025Review
- Novel Buccal Xanthan Gum-Hyaluronic Acid Eutectogels with Dual Anti-Inflammatory and Antimicrobial Properties.Gels (Basel, Switzerland) · 2025Article
- Advanced drug delivery systems for the management of local conditions.Therapeutic delivery · 2025Review
- Review
- Unveiling the Potential of Surface Polymerized Drug Nanocrystals in Targeted Delivery.ACS applied materials & interfaces · 2024Article
- Cationic Curcumin Nanocrystals Liposomes for Improved Oral Bioavailability: Formulation Development, Optimization, In Vitro and In Vivo Evaluation.Pharmaceutics · 2024Article
- Calcipotriol Nanosuspension-Loaded Trilayer Dissolving Microneedle Patches for the Treatment of Psoriasis: In Vitro Delivery and In Vivo Antipsoriatic Activity Studies.Molecular pharmaceutics · 2024Article
- Folic Acid-Decorated Nanocrystals as Highly Loaded Trojan Horses to Target Cancer Cells.Molecular pharmaceutics · 2024Article
- Self-assembled gel microneedle formed by MS deep eutectic solvent as a transdermal delivery system for hyperpigmentation treatment.Materials today. Bio · 2024Article
- Enhanced Anti-Inflammatory Activity of Tilianin Based on the Novel Amorphous Nanocrystals.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas.Pharmaceuticals (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are attracting a great deal of interest in the biomedical space. Herein, we report the first example of adhesive Egels loading drug nanocrystals (Egel-NCs) for controlled delivery to mucosal tissues. These soft materials were prepared using gelatin, glycerine, a deep eutectic solvent (DES) based on choline hydrochloride and glycerol, and nanocrystallised curcumin, a model drug with potent antimicrobial and anti-inflammatory activities. We first explored the impact of the biopolymer concentration on the viscoelastic and mechanical properties of the networks. Thanks to the dynamic interactions between gelatin and the DES, the Egel showed excellent stretchability and elasticity (up to ≈160%), reversible gel-sol phase transition at mild temperature (≈50 °C), 3D-printing ability, and good adhesion to mucin protein (stickiness ≈40 kPa).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.