Evidence map›Paper›PMID 36345156›Full record

SynthesisKorean journal of anesthesiology2023

Single-shot regional anesthesia for laparoscopic cholecystectomies: a systematic review and network meta-analysis.

Alessandro De Cassai, Nicolò Sella, Federico Geraldini, Serkan Tulgar, Ali Ahiskalioglu, Burhan Dost, Silvia Manfrin, Yunus Emre Karapinar, Greta Paganini, Muzeyyen Beldagli and 4 more

2 registry-linked trialsOpen access · goldAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Korean journal of anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07241949 narecruitingnot on this mapstarted 2025, after this paper: background citation

Paravertebral Block or External Oblique Intercostal Block? A Comparative Analysis of Pain and Opioid Consumption After Laparoscopic Cholecystectomy: A Randomized Controlled Trial

TypeinterventionalSponsorCukurova UniversityRan2025 to 2026Enrolled147ConditionsPostoperative Pain, Laparoscopic Cholecystectomy, Paravertebral Block, External Oblique Intercostal Plane BlockArmsParavertebral Block (PVB), External Oblique Intercostal Block (EOI Block), Tramadol IV Patient-Controlled Analgesia (PCA)
NCT07507799 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Analgesic Efficacy of Low-Volume Versus Standard-Volume 0.25% Bupivacaine for Ultrasound-Guided External Oblique and Rectus Abdominis Plane Block in Laparoscopic Cholecystectomy, A Randomized Non-Inferiority Trial

TypeinterventionalSponsorFayoum University HospitalRan2026 to 2026Enrolled96ConditionsPain, Postoperative, Post Operative AnalgesiaArmsEXORA block 15, EXORA block 25
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Alessandro De CassaiUOC Anesthesia and Intensive Care Unit, University Hospital of Padua, Padua, Italy.
Nicolò SellaUOC Anesthesia and Intensive Care Unit, University Hospital of Padua, Padua, Italy.
Federico GeraldiniUOC Anesthesia and Intensive Care Unit, University Hospital of Padua, Padua, Italy.
Serkan TulgarDepartment of Anesthesiology and Reanimation, Samsun Training and Research Hospital, Samsun University Faculty of Medicine, Samsun, Turkey.
Ali AhiskaliogluDepartment of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey.
Burhan DostDepartment of Anesthesiology and Reanimation, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
Silvia ManfrinUOC Anesthesia and Intensive Care Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy.
Yunus Emre KarapinarDepartment of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey.
Greta PaganiniUOC Anesthesia and Intensive Care Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy.
Muzeyyen BeldagliDepartment of Anesthesiology and Reanimation, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
Vittoria LuoniUOC Anesthesia and Intensive Care Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy.
Busra Burcu Kucuk OrduluDepartment of Anesthesiology and Reanimation, Samsun Training and Research Hospital, Samsun University Faculty of Medicine, Samsun, Turkey.
Annalisa BoscoloUOC Anesthesia and Intensive Care Unit, University Hospital of Padua, Padua, Italy.
Paolo NavalesiUOC Anesthesia and Intensive Care Unit, University Hospital of Padua, Padua, Italy.
University of Padua · ITAtatürk University · TROndokuz Mayıs University · TRSamsun University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDifferent regional anesthesia (RA) techniques have been used for laparoscopic cholecystectomy (LC), but there is no consensus on their comparative effectiveness. Our objective was to evaluate the effect of RA techniques on patients undergoing LC using a network meta-analysis approach.

methodsWe conducted a systematic review and network meta-analysis. We searched PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and Web of Science (Science and Social Science Citation Index) using the following PICOS criteria: (P) adult patients undergoing LC; (I) any RA single-shot technique with injection of local anesthetics; (C) placebo or no intervention; (O) postoperative opioid consumption expressed as morphine milligram equivalents (MME), rest pain at 12 h and 24 h post-operation, postoperative nausea and vomiting (PONV), length of stay; and (S) randomized controlled trials.

resultsA total of 84 studies were included. With the exception of the rectus sheath block (P = 0.301), the RA techniques were superior to placebo at reducing opioid consumption. Regarding postoperative pain, the transversus abdominis plane (TAP) block (-1.80 on an 11-point pain scale) and erector spinae plane (ESP) block (-1.33 on an 11-point pain scale) were the most effective at 12 and 24 h. The TAP block was also associated with the greatest reduction in PONV.

conclusionsRA techniques are effective at reducing intraoperative opioid use, postoperative pain, and PONV in patients undergoing LC. Patients benefit the most from the bilateral paravertebral, ESP, quadratus lumborum, and TAP blocks.

Indexed as

Anesthesia, ConductionCholecystectomy, LaparoscopicAdultAnalgesics, OpioidHumansPostoperative Nausea and VomitingPostoperative PainAnalgesics, OpioidCholecystectomyConduction anesthesiaLaparoscopic cholecystectomyLaparoscopyLocal anesthesiaMeta-analysis.

Identifiers

PMID36345156
PMCPMC9902189
OpenAlexW4308549028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.