ArticleBMC geriatrics2022
Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Microbiota-Gut-Brain Axis Mechanisms in Cognitive Impairment Associated with Central Obesity.Current obesity reports · 2026Review
- Obesity-Related Cognitive Impairment: An Update Overview of Mechanisms and Treatments.Expert reviews in molecular medicine · 2026Review
- Association of metabolic obesity phenotypes with cognitive decline in the ELSA-Brasil study.Diabetes, obesity & metabolism · 2026Article
- Systematic analysis of associations between obesity and memory decline.GeroScience · 2026Article
- Association Between Anthropometry and Cognitive Impairment in Patients with Type 2 Diabetes: Secondary Analysis from the 'Cognition in Diabetes' Study.TouchREVIEWS in endocrinology · 2025Article
- Associations between serum lipid levels and cognitive impairment in hypertensive patients: a case-control study.BMC neurology · 2025Article
- Association of adiposity evaluated by anthropometric and bioelectrical impedance analysis measures with cognitive performance in the ELSA-Brasil study.International journal of obesity (2005) · 2025Article
- Longitudinal patterns of cognitive function and depression: insights from the China Health and Retirement Longitudinal Study.Journal of global health · 2025Article
- Associations between eight anthropometric indices and Parkinson's disease: a nationwide population-based study.Frontiers in nutrition · 2025Article
- Development and interpretation of a machine learning predictive model for early cognitive impairment in hypertension associated with environmental factors.Frontiers in cardiovascular medicine · 2025Article
- Body mass index, waist circumference, hip circumference, abdominal volume index, and cognitive function in older Chinese people: a nationwide study.BMC geriatrics · 2024Article
- A comparative study of bibliometric analysis on old adults' cognitive impairment based on Web of Science and CNKI via CiteSpace.Health economics review · 2023Review
- The role of IGF-1 in exercise to improve obesity-related cognitive dysfunction.Frontiers in neuroscience · 2023Review
- A risk prediction model based on machine learning for early cognitive impairment in hypertension: Development and validation study.Frontiers in public health · 2023Article
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Abstract
backgroundObesity adversely influences the central nervous system and cognitive functions. However, the relationship between various obesity indicators and cognitive performance remains controversial. It is unclear which obesity indicator is more relevant to cognitive impairment.
methodsThe Taiwan Biobank (TWB) administered the Chinese version of the Mini-Mental State Examination (MMSE) to 30,697 participants (12,094 males and 18,603 females) aged 60 to 70 years. A total of 3,454 (11.25%) individuals with MMSE < = 24 were classified as having poor cognitive performance. This cross-sectional study investigates the associations of five obesity indicators with cognitive performance. Five separate logistic regression models were fitted for males and another five for females. Covariates adjusted in all models included age, smoking status, drinking status, regular exercise, chronic disease status (diabetes, cardiovascular diseases, heart diseases, stroke, or Parkinson's disease), depression status, blood pressure level, total cholesterol, fasting glucose, and educational attainment. The five obesity indicators included body mass index (BMI), body fat percentage (BFP), waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR).
resultsAbdominal obesity defined by WHR was significantly associated with poor cognitive performance. Male WHR > = 0.90 had a higher risk of poor cognitive performance than male WHR < 0.90 (odds ratio [OR] = 1.233; p = 0.007); female WHR > = 0.85 had an increased risk of poor cognitive performance compared with female WHR < 0.85 (OR = 1.221; p = 3.9E-4). HC and general obesity (defined by BMI and BFP) were not significantly associated with cognitive performance.
conclusionThe results consistently agreed that preventing abdominal obesity is associated with better cognitive performance in both males and females.
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