Evidence map›Paper›PMID 36344847›Full record

ArticleNature structural & molecular biology2022

Cryo-EM structures of prefusion SIV envelope trimer.

Jason Gorman, Chunyan Wang, Rosemarie D Mason, Alexandra F Nazzari, Hugh C Welles, Tongqing Zhou, Julian W Bess, Tatsiana Bylund, Myungjin Lee, Yaroslav Tsybovsky and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Jason GormanVaccine Research Center, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3775-6560
Chunyan Wang *Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.
Rosemarie D Mason *Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Alexandra F Nazzari *Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Hugh C Welles *Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Tongqing Zhou *Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3935-4637
Julian W BessAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0003-0662-7843
Tatsiana BylundVaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Myungjin LeeVaccine Research Center, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4972-3811
Yaroslav TsybovskyElectron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-2159-5248
Raffaello VerardiVaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Shuishu WangVaccine Research Center, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0865-4522
Yongping YangVaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Baoshan ZhangVaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Reda RawiVaccine Research Center, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0445-2325
Brandon F KeeleAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-2381-1151
Jeffrey D LifsonAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Jun LiuDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA. jliu@yale.edu.ORCID http://orcid.org/0000-0003-3108-6735
Mario RoedererVaccine Research Center, National Institutes of Health, Bethesda, MD, USA. roederer@nih.gov.ORCID http://orcid.org/0000-0001-7448-7040
Peter D KwongVaccine Research Center, National Institutes of Health, Bethesda, MD, USA. pdkwong@nih.gov.ORCID http://orcid.org/0000-0003-3560-232X
National Institutes of Health · USFrederick National Laboratory for Cancer Research · USYale University · USLeidos (United States) · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
HIV-1 Env structure and function assessed by parallel smFRET and cryoETR01AI150560 · NIAID · YALE UNIVERSITY · PI BLANCHARD, SCOTT C, LIU, JUN · 2019 to 2022
$3.4M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
CCR NIH HHS HHSN261200800001CNCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261200800001ENIAID NIH HHS R01 AI150560NIGMS NIH HHS P41 GM103310NIH HHS S10 OD023603
6 · The paper itself

Abstract

Simian immunodeficiency viruses (SIVs) are lentiviruses that naturally infect non-human primates of African origin and seeded cross-species transmissions of HIV-1 and HIV-2. Here we report prefusion stabilization and cryo-EM structures of soluble envelope (Env) trimers from rhesus macaque SIV (SIV

Indexed as

Antibodies, NeutralizingHIV-1AnimalsCryoelectron MicroscopyElectron Microscope Tomographyenv Gene Products, Human Immunodeficiency VirusHIV AntibodiesMacaca mulattaAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusHIV Antibodies

Identifiers

PMID36344847
PMCPMC10606957
OpenAlexW4308433986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.