ArticleNature structural & molecular biology2022
Endocrine resistance and breast cancer plasticity are controlled by CoREST.
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Article in Nature structural & molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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Who cites it
24 citing papers in PubMed, 26 citations in OpenAlex.
- The CoREST complex inhibitor, corin, decreases tumor growth, increases cellular differentiation and extends lifespan in ATRT xenograft models.Neuro-oncology · 2026Article
- Unlocking the ferroptotic window: Lipidomic rewiring and metabolic addiction in EMT-driven breast cancer resistance.Cell death discovery · 2026Review
- Sodium-glucose cotransporter 2 inhibitors in breast cancer patients on endocrine therapy: a targeted strategy to mitigate long-term cardiometabolic risk.Journal of translational medicine · 2026Review
- Endocrine therapy-specific lineage and partial epithelial-mesenchymal reprogramming defines divergent resistant cell-states in ER+ breast cancer.bioRxiv : the preprint server for biology · 2026Article
- Game of clones: decipher lineage plasticity in hormone-driven cancers.Cellular and molecular life sciences : CMLS · 2026Review
- Altered chromatin accessibility and nucleosome positioning landscape upon HDAC and LSD1 inhibition in cancer cell.bioRxiv : the preprint server for biology · 2026Article
- Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer.Genes & development · 2026Article
- CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.JCI insight · 2026Article
- Review
- Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML.bioRxiv : the preprint server for biology · 2025Article
- CoREST in pieces: Dismantling the CoREST complex for cancer therapy and beyond.Science advances · 2025Review
- The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors.Scientific reports · 2025Article
- Review
- The scaffolding function of LSD1 controls DNA methylation in mouse ESCs.Nature communications · 2024Article
- Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.Genes & development · 2024Article
- The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma.The Journal of clinical investigation · 2024Article
- RCOR1 is targeted by miR-23b-3p to modulate growth, colony formation, migration, and invasion of prostate cancer cells.International journal of clinical and experimental pathology · 2024Article
- The molecular determinants of phenotypic plasticity in homeostasis and neoplasia.Cancer heterogeneity and plasticity · 2024Article
- MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis.Nature cell biology · 2023Article
- Advancing breast cancer diagnosis with a near-infrared fluorescence imaging smart sensor for estrogen/progesterone receptor detection.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Liliana Garcia-MartinezSylvester Comprehensive Cancer Center, Miami, FL, USA.ORCID http://orcid.org/0000-0002-3015-5543
Andrew M AdamsSylvester Comprehensive Cancer Center, Miami, FL, USA.
Ho Lam ChanSylvester Comprehensive Cancer Center, Miami, FL, USA.ORCID http://orcid.org/0000-0001-9799-0618
Yuichiro NakataSylvester Comprehensive Cancer Center, Miami, FL, USA.
Natalia WeichSylvester Comprehensive Cancer Center, Miami, FL, USA.
Stephanie StranskyDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-0844-2754
Zhao ZhangDepartment of Molecular Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Mohamed AlshalalfaSylvester Comprehensive Cancer Center, Miami, FL, USA.
Leonor SarriaSylvester Comprehensive Cancer Center, Miami, FL, USA.
Brandon A MahalSylvester Comprehensive Cancer Center, Miami, FL, USA.
Susan B KesmodelSylvester Comprehensive Cancer Center, Miami, FL, USA.
Toni Celià-TerrassaCancer Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Zhijie LiuDepartment of Molecular Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-6956-7839
Saverio MinucciDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Daniel BilbaoSylvester Comprehensive Cancer Center, Miami, FL, USA.
Simone SidoliDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0001-9073-6641
Ramiro E VerdunSylvester Comprehensive Cancer Center, Miami, FL, USA. rverdun@med.miami.edu.ORCID http://orcid.org/0000-0003-0530-4807
Lluis MoreySylvester Comprehensive Cancer Center, Miami, FL, USA. lmorey@med.miami.edu.ORCID http://orcid.org/0000-0001-9851-4066
University of Miami · USSylvester Comprehensive Cancer Center · USAlbert Einstein College of Medicine · USThe University of Texas Health Science Center at San Antonio · USHospital Del Mar · ESUniversity of Milan · IT
Funding
Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI George S. Grills · 2019 to 2026
$24.1MIdentify the Mechanisms of LMO2-Mediated Inhibition of Homologous Recombination and Establish PARP-Targeted Synthetic Lethality as a New Therapy for DLBCLR01CA233945 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LOSSOS, IZIDORE S, VERDUN, RAMIRO ERNESTO · 2019 to 2023
$1.8MMechanisms of RING1B and PRC1 complexes in transcriptional activationR01GM141349 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Lluis Morey · 2022 to 2026
$1.6MRole of TRF2 in DNA recombinationR01GM121595 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI VERDUN, RAMIRO ERNESTO · 2017 to 2021
$1.5MOrbitrap Exploris 480 Basic SystemS10OD030286 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SIDOLI, SIMONE · 2021 to 2021
$600kNCI NIH HHS P30 CA240139NCI NIH HHS R01 CA233945NIGMS NIH HHS R01 GM121595NIGMS NIH HHS R01 GM141349NIH HHS S10 OD030286
Abstract
Resistance to cancer treatment remains a major clinical hurdle. Here, we demonstrate that the CoREST complex is a key determinant of endocrine resistance and ER
Indexed as
Breast NeoplasmsCarcinogenesisChromatinCo-Repressor ProteinsFemaleHistone DemethylasesHumansNerve Tissue ProteinsChromatinCo-Repressor ProteinsHistone DemethylasesNerve Tissue Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.