ArticleNature chemistry2023
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors.
Article in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
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- Spatially Encoded Protocell Network for Non-Cascaded Parallel Biocomputation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Photoresponsive Discoidal Polymersomes With Tracelessly Crosslinkable Bilayers for Intracellular Drug Delivery.Angewandte Chemie (International ed. in English) · 2026Article
- Wavelength-dependent feedback behavior in light-gated polymersome nanoreactors.Nature communications · 2026Article
- Autonomous and Communicative Microcapsule Systems for Life-Like Homeostatic pH Regulation.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Reservoir Computing-Based Glucose Sensing With an Enzymatic Reaction Network.Angewandte Chemie (International ed. in English) · 2026Article
- Donor-acceptor covalent adaptable networks.Nature communications · 2026Article
- Hydrogels Incorporating Donor-Acceptor Stenhouse Adducts as a Platform for Photoinduced, On-Off Switchable Release of Small Molecule Cargos.Macromolecular rapid communications · 2026Article
- Photogated two conductive pathways of donor-acceptor Stenhouse adducts in single-molecule junctions.Nature communications · 2026Article
- Molecular systems engineering of synthetic cells.Nature chemistry · 2026Review
- Photochromism of pyridine-substituted merocyanine through reversible C-N bond formation.Nature communications · 2025Article
- Kinetically controlled hetero-fusion is a systems-level behaviour of polymer nanoparticle populations.Nature communications · 2025Article
- Photocleavable Systems for Cell Biology: Conceptual Design across Molecular Modalities.Chembiochem : a European journal of chemical biology · 2025Review
- Enhanced enzyme stability at the interphase of water-oil for continuous-flow olefin epoxidation.Nature communications · 2025Article
- Interfacial assembly of biomimetic MOF-based porous membranes on coacervates to build complex protocells and prototissues.Nature chemistry · 2025Article
- Spatio-Temporal Processes of Diffusion-Controlled Communication in Hierarchical Multi-Compartments.Angewandte Chemie (International ed. in English) · 2025Article
- Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.Nature chemical biology · 2025Article
- Cytomimetic calcification in chemically self-regulated prototissues.Nature communications · 2025Article
- Biomineralization-Inspired Membranization Toward Structural Enhancement of Coacervate Community.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- 4D Assembly of Time-dependent Lanthanide Supramolecular Multicolor Phosphorescence for Encryption and Visual Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
The circadian rhythm generates out-of-equilibrium metabolite oscillations that are controlled by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem comprising a binary population of enzyme-containing polymersomes capable of light-gated chemical communication, controllable feedback and coupling to macroscopic oscillations. The populations consist of esterase-containing polymersomes functionalized with photo-responsive donor-acceptor Stenhouse adducts (DASA) and light-insensitive semipermeable urease-loaded polymersomes. The DASA-polymersome membrane becomes permeable under green light, switching on esterase activity and decreasing the pH, which in turn initiates the production of alkali in the urease-containing population. A pH-sensitive pigment that absorbs green light when protonated provides a negative feedback loop for deactivating the DASA-polymersomes. Simultaneously, increased alkali production deprotonates the pigment, reactivating esterase activity by opening the membrane gate. We utilize light-mediated fluctuations of pH to perform non-equilibrium communication between the nanoreactors and use the feedback loops to induce work as chemomechanical swelling/deswelling oscillations in a crosslinked hydrogel. We envision possible applications in artificial organelles, protocells and soft robotics.
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