Evidence map›Paper›PMID 36344814›Full record

ArticleNPJ digital medicine2022

Multimodal machine learning in precision health: A scoping review.

Adrienne Kline, Hanyin Wang, Yikuan Li, Saya Dennis, Meghan Hutch, Zhenxing Xu, Fei Wang, Feixiong Cheng, Yuan Luo

Registry-linked trialAbstract readScoping Review
In one paragraph

Article in NPJ digital medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07078136 (Multicenter Observational Study of a Multimodal AI Model Using EUS, White-Light Endoscopy, and Clinical Data for Diagnosis of Upper GI Mesenchymal Tumors and Risk Stratification of Gastric GISTs), which is not on this map. Cited by 219 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07078136 recruitingnot on this mapstarted 2025, after this paper: background citation

Multicenter Observational Study of a Multimodal AI Model Using EUS, White-Light Endoscopy, and Clinical Data for Diagnosis of Upper GI Mesenchymal Tumors and Risk Stratification of Gastric GISTs

TypeobservationalSponsorHuazhong University of Science and TechnologyRan2025 to 2026Enrolled130ConditionsSubmucosal Tumor, Gastrointestinal Stromal Tumor (GIST), Leiomyoma, SchwannomaArmsMultimodal AI Model, Expert Endoscopist Assessment
3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  14. Review
  15. From patient notes to prognostication: The revolutionary potential of event-based foundation models in orthopaedics.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
    Article
  16. Article
  17. Article
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  20. Multi-modal learning with incomplete data.Nature communications · 2026
    Article

159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adrienne KlineDepartment of Preventive Medicine, Northwestern University, Chicago, 60201, IL, USA.
Hanyin WangDepartment of Preventive Medicine, Northwestern University, Chicago, 60201, IL, USA.
Yikuan LiDepartment of Preventive Medicine, Northwestern University, Chicago, 60201, IL, USA.
Saya DennisDepartment of Preventive Medicine, Northwestern University, Chicago, 60201, IL, USA.
Meghan HutchDepartment of Preventive Medicine, Northwestern University, Chicago, 60201, IL, USA.
Zhenxing XuDepartment of Population Health Sciences, Cornell University, New York, 10065, NY, USA.
Fei WangDepartment of Population Health Sciences, Cornell University, New York, 10065, NY, USA.ORCID http://orcid.org/0000-0001-9459-9461
Feixiong ChengCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, 44195, OH, USA.
Yuan LuoDepartment of Preventive Medicine, Northwestern University, Chicago, 60201, IL, USA. yuan.luo@northwestern.edu.ORCID http://orcid.org/0000-0003-0195-7456

Funding

CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and LearningU01TR003528 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CIMINO, JAMES J, LUO, YUAN · 2021 to 2024
$4.9M
Alzheimer's MultiOme Data Repurposing: Artificial Intelligence, Network Medicine, and Therapeutics DiscoveryU01AG073323 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI BEKRIS, LYNN, CHENG, FEIXIONG · 2021 to 2025
$4.0M
Modeling the Incompleteness and Biases of Health DataR01LM013337 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, YUAN · 2020 to 2023
$1.3M
NCATS NIH HHS U01 TR003528NIA NIH HHS U01 AG073323NLM NIH HHS R01 LM013337
6 · The paper itself

Abstract

Machine learning is frequently being leveraged to tackle problems in the health sector including utilization for clinical decision-support. Its use has historically been focused on single modal data. Attempts to improve prediction and mimic the multimodal nature of clinical expert decision-making has been met in the biomedical field of machine learning by fusing disparate data. This review was conducted to summarize the current studies in this field and identify topics ripe for future research. We conducted this review in accordance with the PRISMA extension for Scoping Reviews to characterize multi-modal data fusion in health. Search strings were established and used in databases: PubMed, Google Scholar, and IEEEXplore from 2011 to 2021. A final set of 128 articles were included in the analysis. The most common health areas utilizing multi-modal methods were neurology and oncology. Early fusion was the most common data merging strategy. Notably, there was an improvement in predictive performance when using data fusion. Lacking from the papers were clear clinical deployment strategies, FDA-approval, and analysis of how using multimodal approaches from diverse sub-populations may improve biases and healthcare disparities. These findings provide a summary on multimodal data fusion as applied to health diagnosis/prognosis problems. Few papers compared the outputs of a multimodal approach with a unimodal prediction. However, those that did achieved an average increase of 6.4% in predictive accuracy. Multi-modal machine learning, while more robust in its estimations over unimodal methods, has drawbacks in its scalability and the time-consuming nature of information concatenation.

Identifiers

PMID36344814
PMCPMC9640667

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.