Evidence map›Paper›PMID 36344807›Full record

ArticleScientific reports2022

Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk.

Cameron B Haas, Yu-Ru Su, Paneen Petersen, Xiaoliang Wang, Stephanie A Bien, Yi Lin, Demetrius Albanes, Stephanie J Weinstein, Mark A Jenkins, Jane C Figueiredo and 31 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Role of dietary nutrients and metabolism in colorectal cancer.Asia Pacific journal of clinical nutrition · 2024
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 8 countries.

Cameron B HaasDepartment of Epidemiology, University of Washington, Seattle, WA, USA. cameron.b.haas@gmail.com.
Yu-Ru SuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Paneen PetersenPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Xiaoliang WangPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Victor MorenoOncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Stephen B GruberDepartment of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Michael O WoodsMemorial University of Newfoundland, Discipline of Genetics, St. John's, Canada.
Steven J GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Sonja BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Richard B HayesDivision of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Emily WhiteDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Hongmei NanIU Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura'a University, Makkah, Saudi Arabia.
Noralane M LindorDepartment of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.
Juan P LewingerDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Andre E KimDepartment of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David ContiDepartment of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
W James GaudermanDepartment of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Ulrike PetersDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Seattle University · USUniversity of Southern California · USFred Hutch Cancer Center · USNational Cancer Institute · USUniversity of Virginia · USAmerican Cancer Society · USBrigham and Women's Hospital · USCarmel Medical Center · ILIndiana University – Purdue University Indianapolis · USInstitut d'Investigació Biomédica de Bellvitge · ESKaiser Permanente · USKarolinska Institutet · SELunenfeld-Tanenbaum Research Institute · CAMayo Clinic in Arizona · USMemorial University of Newfoundland · CAMonash Health · AUMonash University · AUNational Institutes of Health · USNew York University · USUmm al-Qura University · SA

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Molecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8M
NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA114347NCI NIH HHS R01 CA136726NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R35 CA197735NCI NIH HHS R37 CA054281NCI NIH HHS T32 CA094880NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA167552NCI NIH HHS U19 CA148107NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NCI NIH HHS Z01 CP010200NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200008INIA NIH HHS HHSN271201100004CNIEHS NIH HHS T32 ES013678NIH HHS T32 CA094880WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Observational studies have shown higher folate consumption to be associated with lower risk of colorectal cancer (CRC). Understanding whether and how genetic risk factors interact with folate could further elucidate the underlying mechanism. Aggregating functionally relevant genetic variants in set-based variant testing has higher power to detect gene-environment (G × E) interactions and may provide information on the underlying biological pathway. We investigated interactions between folate consumption and predicted gene expression on colorectal cancer risk across the genome. We used variant weights from the PrediXcan models of colon tissue-specific gene expression as a priori variant information for a set-based G × E approach. We harmonized total folate intake (mcg/day) based on dietary intake and supplemental use across cohort and case-control studies and calculated sex and study specific quantiles. Analyses were performed using a mixed effects score tests for interactions between folate and genetically predicted expression of 4839 genes with available genetically predicted expression. We pooled results across 23 studies for a total of 13,498 cases with colorectal tumors and 13,918 controls of European ancestry. We used a false discovery rate of 0.2 to identify genes with suggestive evidence of an interaction. We found suggestive evidence of interaction with folate intake on CRC risk for genes including glutathione S-Transferase Alpha 1 (GSTA1; p = 4.3E-4), Tonsuko Like, DNA Repair Protein (TONSL; p = 4.3E-4), and Aspartylglucosaminidase (AGA: p = 4.5E-4). We identified three genes involved in preventing or repairing DNA damage that may interact with folate consumption to alter CRC risk. Glutathione is an antioxidant, preventing cellular damage and is a downstream metabolite of homocysteine and metabolized by GSTA1. TONSL is part of a complex that functions in the recovery of double strand breaks and AGA plays a role in lysosomal breakdown of glycoprotein.

Indexed as

Colorectal NeoplasmsFolic AcidCase-Control StudiesGene ExpressionHumansNF-kappa BRiskRisk FactorsFolic AcidNF-kappa BTONSL protein, human

Identifiers

PMID36344807
PMCPMC9640550
OpenAlexW4308391892

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.