Evidence map›Paper›PMID 36344770›Full record

Trial reportEuropean journal of nutrition2023

The effect of iron supplementation on maternal iron deficiency anemia does not differ by baseline anemia type among Tanzanian pregnant women without severe iron deficiency anemia.

Ajibola Ibraheem Abioye, Michael D Hughes, Christopher R Sudfeld, Zulfiqarali Premji, Said Aboud, Davidson H Hamer, Drucilla J Roberts, Christopher P Duggan, Wafaie W Fawzi

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01119612 (Prenatal Iron Supplements), which is not on this map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01119612 nacompletednot on this map

Prenatal Iron Supplements: Safety and Efficacy in Tanzania

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2010 to 2013Enrolled1,500ConditionsMalaria, AnemiaArmsIron, Placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Ajibola Ibraheem AbioyeDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard T.H. School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. iaa551@g.harvard.edu.ORCID http://orcid.org/0000-0002-6632-613X
Michael D HughesDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Christopher R SudfeldDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard T.H. School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Zulfiqarali PremjiDepartment of Pathology, Aga Khan University, Nairobi, Kenya.
Said AboudDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Davidson H HamerDepartment of Global Health, School of Public Health, Boston University, Boston, MA, USA.
Drucilla J RobertsDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Christopher P DugganDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard T.H. School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Wafaie W FawziDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard T.H. School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Harvard University · USAga Khan University Nairobi · KEBoston Children's Hospital · USBoston University · USMassachusetts General Hospital · USMuhimbili University of Health and Allied Sciences · TZ

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Prenatal Iron Supplements: Safety & Efficacy in TanzaniaU01HD061232 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2009 to 2014
$1.6M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
Eunice Kennedy Shriver National Institute of Child Health and Human Development U01 HD061232NICHD NIH HHS U01 HD061232NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

purposeWhether anemia type modifies the risk of pregnancy and newborn outcomes and the effectiveness of iron supplementation is unclear. We examined the association of iron deficiency anemia (IDA) and non-iron deficiency anemia (NIDA) on the risks of these outcomes and the extent to which anemia type modifies the impact of prenatal iron supplementation.

methodsThis was a secondary analysis of a placebo-controlled trial of iron supplementation among 1450 HIV-negative women in Tanzania. Eligibility criteria included gestational age < 27 weeks, hemoglobin > 85 g/L, and ferritin > 12 µg/L. Individuals were categorized as non-anemia, IDA or NIDA using hemoglobin, ferritin and CRP. Analyses were conducted using regression models and likelihood ratio tests.

resultsCompared to the non-anemia group, delivery hemoglobin was lower by 15 g/L (95% CI 10.9, 19.3) in the baseline IDA group, and 7.3 g/L (95% CI 3.1, 11.5) in the baseline NIDA group. The RRs of anemia severity, iron deficiency, placental malaria, stillbirths, perinatal mortality, birthweight, and preterm birth were not different among women in the baseline NIDA group (vs. non-anemia) compared to the baseline IDA group (vs. non-anemia). The difference in the mean delivery hemoglobin for iron supplementation and placebo arms was 8 g/L (95% CI 6, 11) in the non-anemia group, 7 g/L (95% CI 2, 13) in the NIDA group, and 16 g/L (95% CI 10, 22) in the IDA group.

conclusionIron supplementation is effective even among pregnant women with NIDA.

trial registrationNCT01119612 (May 7, 2010).

Indexed as

AnemiaAnemia, Iron-DeficiencyPremature BirthDietary SupplementsFemaleFerritinsHemoglobinsHumansInfantInfant, NewbornNitrosaminesPlacentaPregnancyPregnant PeopleTanzaniaFerritinsHemoglobinsNitrosaminesN-nitrosoiminodiacetic acidAnemiaInflammationIronIron deficiencyPregnancy

Identifiers

PMID36344770
PMCPMC9987582
OpenAlexW4308555644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.