Evidence map›Paper›PMID 36344740›Full record

ArticleScientific reports2022

Association of treatment delay and stage with mortality in breast cancer: a nationwide cohort study in Taiwan.

Nai-Chen Shih, Pei-Tseng Kung, Wei-Yin Kuo, Wen-Chen Tsai

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  7. Association between chemotherapy and the risk of developing breast cancer-related lymphedema: a nationwide retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  13. Prevalence ofFrontiers in oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nai-Chen ShihDepartment of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Pei-Tseng Kung *Department of Healthcare Administration, Asia University, Taichung, Taiwan, R.O.C.
Wei-Yin KuoDepartment of Health Services Administration, China Medical University, Taichung, Taiwan, R.O.C., No. 100, Sec. 1, Jingmao Rd., Beitun Dist., 406040.
Wen-Chen Tsai *Department of Health Services Administration, China Medical University, Taichung, Taiwan, R.O.C., No. 100, Sec. 1, Jingmao Rd., Beitun Dist., 406040. wctsai2011@gmail.com.

Funding

China Medical University and Asia University CMU110-ASIA-12the Ministry of Science and Technology, Taiwan MOST104-2410-H-039 -002
6 · The paper itself

Abstract

Breast cancer is the fifth leading cause of cancer death globally. In this retrospective study, we investigated the effects of the diagnosis-to-first-treatment interval (DFTI) and other related factors on cancer-specific survival in patients with breast cancer. We included 49,426 patients newly diagnosed as having breast cancer during 2011-2017. The Cox proportional hazards model was used to analyze the hazard ratio (HR) for mortality with various DFTIs; the HRs of the 31-60-, 61-90-, and ≥ 91-day DFTI groups did not differ significantly compared with the reference group (DFTI ≤ 30 days). After stratifying the patients according to initial tumor stage and age, we found that patients aged 55-64 and ≥ 65 years with stage II breast cancer treated ≥ 91 days after diagnosis had a 3.34- and 2.93-fold higher mortality risk (95% confidence intervals [CIs] 1.29-8.69 and 1.06-8.10, respectively). Patients aged ≥ 65 years with stage IV breast cancer treated within 61-90 or ≥ 91 days after diagnosis had a 7.14- and 34.78-fold higher mortality risk (95% CIs 1.28-39.82 and 3.08-393.32, respectively). In conclusion, DFTI is associated with mortality in patients with stage II and IV breast cancer, especially at an older age.

Indexed as

Breast NeoplasmsAgedCohort StudiesFemaleHumansNeoplasm StagingProportional Hazards ModelsRetrospective StudiesTaiwanTime-to-Treatment

Identifiers

PMID36344740
PMCPMC9640724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.