ArticleWorld journal of urology2022
A side-specific nomogram for extraprostatic extension may reduce the positive surgical margin rate in radical prostatectomy.
Article in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Predicting side-specific extraprostatic extension in prostate cancer using an 18F-DCFPyL PSMA-PET/CT-based nomogram.Prostate cancer and prostatic diseases · 2026Article
- Lesion-based grading system using clinicopathological and MRI features for predicting positive surgical margins in prostate cancer.Abdominal radiology (New York) · 2025Article
- Unveiling predictors of positive surgical margins in Retzius-sparing and anterograde robot-assisted radical prostatectomy: insights from a dual-centre learning curve experience.Journal of robotic surgery · 2025Article
- External validation of nomograms including MRI features for the prediction of side-specific extraprostatic extension.Prostate cancer and prostatic diseases · 2024Article
- Histogram analysis of MR quantitative parameters: are they correlated with prognostic factors in prostate cancer?Abdominal radiology (New York) · 2024Article
- Article
- A Novel Nomogram for Identifying the Patients at Risk for Rapid Progression of Advanced Hormone-Sensitive Prostate Cancer.Cancer management and research · 2023Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNomograms predicting side-specific extraprostatic extension (EPE) may be applied to reduce positive surgical margin (PSM) rates in patients planned for radical prostatectomy (RP). This study evaluates the impact of implementing an externally validated nomogram for side-specific EPE on PSM rate and degree of nerve-sparing.
methodsIn patients planned for RP, the side-specific nomogram predictions (based on MRI, ISUP grade group, and PSA density), with an advised threshold of 20% for safe nerve-sparing, were presented preoperatively to the urological surgeon. The surgeon completed a survey before RP about the planning with respect to side-specific nerve-sparing and change of management due to the result of the nomogram. PSM rates and degree of nerve-sparing were compared to a retrospective control group treated in the months prior to the introduction of the nomogram.
resultsA total of 100 patients were included, 50 patients in both groups representing 200 prostate lobes. Of the patients, 37% had histologically confirmed EPE, and 40% a PSM. In 12% of the 100 lobes planned after nomogram presentation, a change in management due to the nomogram was reported. A per-prostate lobe analysis of all the lobes showed comparable rates of full nerve-sparing (45% vs. 30%; p = 0.083) and lower rates of PSM on the lobes with histological EPE (45% vs. 85%; p < 0.05) in the intervention (nomogram) group versus the control group.
conclusionImplementing a predictive nomogram for side-specific EPE in the surgical planning for nerve-sparing leads to lower rates PSM on the side of the histological EPE without compromising nerve-sparing.
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