ArticleNature human behaviour2023
Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles.
Article in Nature human behaviour, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Regional Brain Volume Variation Across Adulthood: A Cross-Sectional MRI Analysis of Age, Sex, and Hemispheric Asymmetry.Life (Basel, Switzerland) · 2026Article
- Parent-of-origin effects in Alzheimer's liability dissociate neurocognitive and cardiovascular traits in at-risk individuals.Cell reports. Medicine · 2026Article
- Variations of global brain asymmetry are associated with aging and related diseases.Science advances · 2026Article
- Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.Brain structure & function · 2026Article
- Cell type transcriptomic modules reveal shared molecular mechanisms in Alzheimer's and Parkinson's disease.GigaScience · 2026Article
- Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts.Nature communications · 2025Article
- Longitudinal changes in brain asymmetry track lifestyle and disease.Nature communications · 2025Article
- Multimodal population study reveals the neurobiological underpinnings of chronotype.Nature human behaviour · 2025Article
- Gate Control Mechanisms of Autoencoders for EEG Signal Reconstruction.Sensors (Basel, Switzerland) · 2025Article
- Pain can't be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design.BMC medicine · 2024Article
- Heritability of cerebellar subregion volumes in adolescent and young adult twins.Human brain mapping · 2024Article
- Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie Alzheimer's disease progression.Communications biology · 2024Article
- Longitudinal microstructural changes in 18 amygdala nuclei resonate with cortical circuits and phenomics.Communications biology · 2024Article
- Brain asymmetries from mid- to late life and hemispheric brain age.Nature communications · 2024Article
- Evolution of Human Brain Left-Right Asymmetry: Old Genes with New Functions.Molecular biology and evolution · 2023Article
- Language network lateralization is reflected throughout the macroscale functional organization of cortex.Nature communications · 2023Article
- Homotopic local-global parcellation of the human cerebral cortex from resting-state functional connectivity.NeuroImage · 2023Article
- Associations of macular microvascular parameters with cerebral small vessel disease in rural older adults: A population-based OCT angiography study.Frontiers in neurology · 2023Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Broca reported ~150 years ago that particular lesions of the left hemisphere impair speech. Since then, other brain regions have been reported to show lateralized structure and function. Yet, studies of brain asymmetry have limited their focus to pairwise comparisons between homologous regions. Here, we characterized separable whole-brain asymmetry patterns in grey and white matter structure from n = 37,441 UK Biobank participants. By pooling information on left-right shifts underlying whole-brain structure, we deconvolved signatures of brain asymmetry that are spatially distributed rather than locally constrained. Classically asymmetric regions turned out to belong to more than one asymmetry pattern. Instead of a single dominant signature, we discovered complementary asymmetry patterns that contributed similarly to whole-brain asymmetry at the population level. These asymmetry patterns were associated with unique collections of phenotypes, ranging from early lifestyle factors to demographic status to mental health indicators.
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