SynthesisMaternal and child health journal2023
Association Between Maternal Factors and Risk of Congenital Heart Disease in Offspring: A Systematic Review and Meta-Analysis.
Synthesis in Maternal and child health journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Maternal adiposity and perinatal and offspring outcomes: an umbrella review.Nature human behaviour · 2024Pooled it
- Maternal factors increase risk of orofacial cleft: a meta-analysis.Scientific reports · 2024Pooled it
- Maternal modifiable factors and risk of congenital heart defects: systematic review and causality assessment.BMJ open · 2024Pooled it
- Targeting metabolism to protect fertility and healthy pregnancy with SGLT2 inhibitors and GLP-1RAs.Current opinion in physiology · 2026Article
- In Utero Diagnosis of Premature Closure of the Foramen Ovale: A Retrospective Case Series Analyzing Neonatal Interventions and Maternal Factors.Pediatric cardiology · 2026Article
- Postpartum adjustment among women with heart disease in pregnancy: a qualitative study.BMC pregnancy and childbirth · 2026Article
- The Impact of Maternal Obesity and Diabetes on the Development of Congenital Heart Defects (CHDs) in Offspring: A Narrative Review.Metabolites · 2026Review
- Intestinal Atresia in Finland: Maternal Risk Factors, Prevalence, Associated Anomalies and Survival.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity.Journal of the American Heart Association · 2026Article
- Does Maternal Smoking Increase the Risk of Congenital Heart Disease? Insights from a Single-Center Fetal Echocardiography Study.Journal of clinical medicine · 2026Article
- Using big data to search for possible geographic clustering of Congenital Heart Disease (CHD) across Australia.PLOS digital health · 2026Article
- Global Burden of Pediatric Cardiovascular Diseases of Congenital and Non-Congenital Trends from 1992 to 2021.Communications medicine · 2026Article
- Epidemiology of congenital heart defects in live births: findings from a study in Southern Brazil.BMC cardiovascular disorders · 2026Article
- Long-term survival and complications of Fontan patients: where do we stand?American journal of cardiovascular disease · 2026Review
- The influence of paternal preconception health on birth defects and head circumference: A scoping review.PLOS global public health · 2026Article
- Review
- Prevalence, risk factors and mortality associated with colonic atresia: a population-based case-control study.Pediatric surgery international · 2025Article
- Risk assessment of congenital heart defects based on maternal factors in early pregnancy-a systematic review and meta-analysis.Frontiers of medicine · 2025Review
- Exploring Breastfeeding Practices and Obstacles Among Mothers With and Without Congenital Heart Disease.Healthcare (Basel, Switzerland) · 2025Article
- Fetal echocardiography in an Arab population: indications and findings from a tertiary care center.The international journal of cardiovascular imaging · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to summarize the evidence describing the relationship between maternal factors during gestation and risk of congenital heart disease (CHD) in offspring.
methodsPubMed, EMBASE, and the Cochrane Library were searched for potentially relevant reports from inception to May 2021. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) calculated by the random-effects model were used to evaluate the association between maternal factors and CHD risk.
resultsThere was a significant association between CHD risk and obesity in pregnancy (OR 1.29, 95% CI 1.22-1.37; P < 0.001), smoking in pregnancy (OR 1.16, 95% CI 1.07-1.25; P < 0.001), maternal diabetes (OR 2.65, 95% CI 2.20-3.19; P < 0.001), and exposure of pregnant women to organic solvents (OR 1.82, 95% CI 1.23-2.70; P = 0.003). No correlations were revealed between CHD susceptibility and advanced maternal age (OR 1.04, 95% CI 0.96-1.12; P = 0.328), underweight (OR 1.02, 95% CI 0.96-1.08; P = 0.519), alcohol intake in pregnancy (OR 1.08, 95% CI 0.95-1.22; P = 0.251), coffee intake (OR 1.18, 95% CI 0.97-1.44; P = 0.105), and exposure to irradiation (OR 1.80, 95% CI 0.85-3.80; P = 0.125). DISCUSSION: Maternal factors including maternal obesity, smoking in pregnancy, maternal diabetes and exposure to organic solvents might predispose the offspring to CHD risk.
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