ArticleScientific reports2022
Comparative and pangenomic analysis of the genus Streptomyces.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
- Bioconversion of agricultural waste to ε-poly-L-lysine by an engineered Streptomyces albulus strain.World journal of microbiology & biotechnology · 2026Article
- Complete Genome Sequencing of Streptomyces sp. Qhu-M197 Isolated from Alpine Meadows in the Qinghai-Tibetan Plateau Uncovers Biosynthetic Gene Clusters Encoding Bioactive Natural Products.Biochemical genetics · 2026Article
- Polyphasic taxonomic characterization of Brachybacterium netajii sp. nov., a metabolically versatile bacterium isolated from the river Ganges, India.Scientific reports · 2026Article
- Nocardia fodinahabitans sp. nov. isolated from underground hard coal mine waters shows biotechnological potential for degradation of aromatic hydrocarbons.Molecular genetics and genomics : MGG · 2026Article
- Genome mining of amylases and amylase inhibitors fromMicrobial genomics · 2026Article
- Functional Assessment of Orphan Proteins in theMicroorganisms · 2026Article
- Genomic insights and biosynthetic gene cluster analysis ofMicrobiology spectrum · 2026Article
- Salt supplementation-induced metabolic reprogramming inmSystems · 2026Article
- Actinolactomycin fromMolecules (Basel, Switzerland) · 2026Article
- DAP-seq Reveals Cluster-Situated Regulator Control of NumerousbioRxiv : the preprint server for biology · 2026Article
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- Integrated multi-omics and genome mining strategies for activating cryptic polyketide biosynthetic gene clusters inFrontiers in microbiology · 2026Review
- Comparative genomics of the Streptomyces genus: insights into multi-stress-resistant genes for bioremediation.World journal of microbiology & biotechnology · 2025Article
- Isolation, Genomic Taxonomy, and Genome Characterization of Streptomyces fradiae SS162, Which has Antibacterial Activity Against Vibrio parahaemolyticus.Current microbiology · 2025Article
- Genomic insights into biosynthesis and adaptation in the bioactive marine bacterium Streptomyces albidoflavus VIP-1 from the Red Sea.BMC microbiology · 2025Article
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- Characterization of the family-levelmBio · 2025Article
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- Comparative Genomics of Sigma Factors inMicroorganisms · 2025Article
- Comprehensive analysis of orthologous genes reveals functional dynamics and energy metabolism in the rhizospheric microbiome of Moringa oleifera.Functional & integrative genomics · 2025Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Streptomycetes are highly metabolically gifted bacteria with the abilities to produce bioproducts that have profound economic and societal importance. These bioproducts are produced by metabolic pathways including those for the biosynthesis of secondary metabolites and catabolism of plant biomass constituents. Advancements in genome sequencing technologies have revealed a wealth of untapped metabolic potential from Streptomyces genomes. Here, we report the largest Streptomyces pangenome generated by using 205 complete genomes. Metabolic potentials of the pangenome and individual genomes were analyzed, revealing degrees of conservation of individual metabolic pathways and strains potentially suitable for metabolic engineering. Of them, Streptomyces bingchenggensis was identified as a potent degrader of plant biomass. Polyketide, non-ribosomal peptide, and gamma-butyrolactone biosynthetic enzymes are primarily strain specific while ectoine and some terpene biosynthetic pathways are highly conserved. A large number of transcription factors associated with secondary metabolism are strain-specific while those controlling basic biological processes are highly conserved. Although the majority of genes involved in morphological development are highly conserved, there are strain-specific varieties which may contribute to fine tuning the timing of cellular differentiation. Overall, these results provide insights into the metabolic potential, regulation and physiology of streptomycetes, which will facilitate further exploitation of these important bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.