ArticleNature communications2022
Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Prioritizing Detailed Item Memories Through Post-Encoding Motivation Requires Consolidation.Open mind : discoveries in cognitive science · 2026Article
- An Integrative Appraisal Model of Epistemic Curiosity.Affective science · 2025Review
- Curiosity shapes spatial exploration and cognitive map formation in humans.Communications psychology · 2024Article
- The magic, memory, and curiosity fMRI dataset of people viewing magic tricks.Scientific data · 2024Article
- Curiosity Satisfaction Increases Event-related Potentials Sensitive to Reward.Journal of cognitive neuroscience · 2024Article
- Hippocampal Functions Modulate Transfer-Appropriate Cortical Representations Supporting Subsequent Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- High performers demonstrate greater neural synchrony than low performers across behavioral domains.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Differential effects of expectancy on memory formation in young and older adults.Human brain mapping · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The hippocampus has been a focus of memory research since H.M's surgery abolished his ability to form new memories, yet its mechanistic role in memory remains debated. Here, we identify a candidate memory mechanism: an anticipatory hippocampal "convergence state", observed while awaiting valuable information, and which predicts subsequent learning. During fMRI, participants viewed trivia questions eliciting high or low curiosity, followed seconds later by its answer. We reasoned that encoding success requires a confluence of conditions, so that hippocampal states more conducive to memory formation should converge in state space. To operationalize convergence of neural states, we quantified the typicality of multivoxel patterns in the medial temporal lobes during anticipation and encoding of trivia answers. We found that the typicality of anticipatory hippocampal patterns increased during high curiosity. Crucially, anticipatory hippocampal pattern typicality increased with dopaminergic midbrain activation and uniquely accounted for the association between midbrain activation and subsequent recall. We propose that hippocampal convergence states may complete a cascade from motivation and midbrain activation to memory enhancement, and may be a general predictor of memory formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.