Evidence map›Paper›PMID 36344478›Full record

ArticleJournal of Korean Neurosurgical Society2022

Preliminary Study on Natural Killer Cell Activity for Interferon-Gamma Production after Gamma Knife Radiosurgery for Brain Tumors.

Kawngwoo Park, Sang Soon Jeong, Jung Hoon Kim, Hyun-Tai Chung, Eun Jung Lee, Hyo Eun Moon, Kwang Hyon Park, Jin Wook Kim, Hye Ran Park, Jae Meen Lee and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean Neurosurgical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Kawngwoo ParkDepartment of Neurosurgery, Gachon University Gil Medical Center, Incheon, Korea.
Sang Soon JeongDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Jung Hoon KimDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Hyun-Tai ChungDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Eun Jung LeeDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Hyo Eun MoonDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Kwang Hyon ParkDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Jin Wook KimDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Hye Ran ParkDepartment of Neurosurgery, Soonchunhyang University Hospital, Seoul, Korea.
Jae Meen LeeDepartment of Neurosurgery, Pusan National University Hospital, Busan, Korea.
Hye Ja LeeDepartment of R & D, NK MAX Company, Sungnam, Korea.
Hye Rim KimDepartment of R & D, NK MAX Company, Sungnam, Korea.
Yong Hwan ChoDepartment of R & D, NK MAX Company, Sungnam, Korea.
Sun Ha PaekDepartment of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Seoul National University · KRPusan National University Hospital · KRSoonchunhyang University Hospital Seoul · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHigh-dose radiation is well known to induce and modulate the immune system. This study was performed to evaluate the correlation between clinical outcomes and changes in natural killer cell activity (NKA) after Gamma Knife Radiosurgery (GKS) in patients with brain cancer.

methodsWe performed an open-label, prospective, cross-sectional study of 38 patients who were treated with GKS for brain tumors, including metastatic and benign brain tumors. All of the patients underwent GKS, and blood samples were collected before and after GKS. NKA was measured using an enzyme-linked immunosorbent assay kit, to measure interferon-gamma (IFNγ) secreted by ex vivo-stimulated NK cells from whole blood. We explored the correlations between NK cell-produced IFNγ (NKA-IFNγ) levels and clinical parameters of patients who were treated with GKS for brain tumors.

resultsNKA-IFNγ levels were decreased in metastatic brain tumor patients compared to those with benign brain tumors (p<0.0001). All the patients who used steroid treatment to reduce brain swelling after GKS had an NKA-IFNγ level of zero except one patient. High NKA-IFNγ levels were not associated with a rapid decrease in brain metastasis and did not increase after GKS.

conclusionThe activity of NK cells in metastatic brain tumors decreased more than that in benign brain tumors after GKS.

Indexed as

Gamma Knife RadiosurgeryInterferon-gammaNatural killer cell

Identifiers

PMID36344478
PMCPMC9666231
OpenAlexW4307872242

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.