Evidence map›Paper›PMID 36344366›Full record

ArticleChinese journal of traumatology = Zhonghua chuang shang za zhi2023

Effects of orientation and distance of goats on blast lung injury characteristics on a plateau above 4500-meter.

Zhao-Xia Duan, Guan-Hua Li, Jie-Yuan Zhang, Meng-Sheng Deng, Kui-Jun Chen, Liang-Chao Zhang, Xiang-Yun Cheng, Jing Chen, Guang-Ming Yang, Jian-Min Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Prediction of primary blast lung injury outcomes in goats using CT and injury factors.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
  3. Article
  4. Article
  5. Dynamic pathophysiological features of early primary blast lung injury: a novel functional incapacity pig model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zhao-Xia DuanDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Guan-Hua LiDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Jie-Yuan ZhangDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Meng-Sheng DengDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Kui-Jun ChenDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Liang-Chao ZhangDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Xiang-Yun ChengDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Jing ChenDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Guang-Ming YangDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China.
Jian-Min WangDepartment of Weapon Bioeffect Assessment, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China. Electronic address: jmwang@tmmu.edu.cn.
Army Medical University · CNDaping Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHigh explosives are used to produce blast waves to study their biological effects. The lungs are considered as the critical target organ in blast-effect studies. The degree of lung hemorrhaging is related to both the explosive power and the increased lung weight. We studied the characteristics of the biological effects from an air explosion of a thermobaric bomb in a high-altitude environment and the lethality and lung injury severity of goats in different orientations and distances.

methodsGoats were placed at 2.5, 3, 4, and 5 m from the explosion center and exposed them to an air blast at an altitude of 4700-meter. A group of them standing oriented to the right side and the other group seated facing the explosion center vertically. The lung injuries were quantified according to the percentage of surface area contused, and using the pathologic severity scale of lung blast injury (PSSLBI) to score the 4 injury categories (slight, moderate, serious and severe) as 1, 2, 3, and 4, respectively. The lung coefficient (lung weight [g]/body weight [kg]) was the indicator of pulmonary edema and was related to lung injury severity. Blast overpressure data were collected using blast test devices placed at matching locations to represent loadings to goats. All statistical analyses were performed using SPSS, version 26.0, statistical software (SPSS, Inc., Chicago, IL, USA).

resultsIn total, 127 goats were involved in this study. Right-side-standing goats had a significantly higher mortality rate than those seated vertical-facing (p < 0.05). At the 2.5 m distance, the goat mortality was nearly 100%, whereas at 5 m, all the goats survived. Lung injuries of the right-side-standing goats were 1 - 2 grades more serious than those of seated goats at the same distances, the scores of PSSLBI were significantly higher than the seated vertical-facing goats (p < 0.05). The lung coefficient of the right-side-standing goats were significantly higher than those of seated vertical-facing (p < 0.05). Mortality, PSSLBI, and the lung coefficient results indicated that the right-side-standing goats experienced severer injuries than the seated vertical-facing goats, and the injuries were lessened as the distance increased. The blast overpressure was consistent with these results.

conclusionThe main killing factors of the thermobaric bomb in the high-altitude environment were blast overpressure, blast wind propulsions and burn. The orientation and distances of the goats significantly affected the blast injury severity. These results may provide a research basis for diagnosing, treating and protecting against injuries from thermobaric explosions.

Indexed as

Blast InjuriesLung InjuryAnimalsExplosionsGoatsLungBlast injuriesLung injuryPlateau

Identifiers

PMID36344366
PMCPMC10244254
OpenAlexW4296177791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.