Evidence map›Paper›PMID 36344135›Full record

ArticleChest2022

A 52-Year-Old Man With Chest Pain and Dyspnea.

Charles G Murphy, Jonathan M Goldstein, Sepideh Besharati, Serge Kobsa, Mary M Salvatore, Erika B Rosenzweig, Matthew Ingham, Armando Del Portillo, Koji Takeda, Subani Chandra and 1 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Charles G MurphyDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY. Electronic address: cgm2156@cumc.columbia.edu.
Jonathan M GoldsteinDepartment of Radiology, Columbia University Irving Medical Center, New York, NY.
Sepideh BesharatiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
Serge KobsaDivision of Cardiac, Thoracic and Vascular Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, NY.
Mary M SalvatoreDepartment of Radiology, Columbia University Irving Medical Center, New York, NY.
Erika B RosenzweigDivision of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY.
Matthew InghamDivision of Hematology and Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
Armando Del PortilloDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
Koji TakedaDivision of Cardiac, Thoracic and Vascular Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, NY.
Subani ChandraDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
David FurfaroDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Columbia University Irving Medical Center · USBeth Israel Deaconess Medical Center · US

Funding

The Columbia University Training Program in Lung ScienceT32HL105323 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jahar Bhattacharya, Wellington V. Cardoso · 2011 to 2026
$4.7M
NHLBI NIH HHS T32 HL105323
6 · The paper itself

Abstract

case presentationA 52-year-old man came to the cardiac surgery clinic for pulmonary thromboendarterectomy (PTE) evaluation. He had initially appeared at an outside hospital 1 year earlier, with chest pain and shortness of breath. He had no known chronic conditions. A CT pulmonary angiogram (CTPA) at that time showed a filling defect at the bifurcation of the main pulmonary artery. A transthoracic echocardiogram revealed mild mitral valve regurgitation, but otherwise the results were normal. As he was hemodynamically stable and not hypoxemic, he was treated solely by anticoagulation. Despite adhering to prescribed apixaban, he developed progressive dyspnea and reduced exercise tolerance over the subsequent year. A repeat CTPA performed 12 months after the initial presentation showed a persistent filling defect at the level of the pulmonary artery bifurcation, with a new extension now completely occluding the right main pulmonary artery. A pulmonary angiogram confirmed this complete occlusion, and right heart catheterization revealed precapillary pulmonary hypertension, with a mean pulmonary artery pressure of 50 mm Hg. His anticoagulation was transitioned to enoxaparin for presumed apixaban treatment failure, and an investigation for hypercoagulable conditions was initiated. His lupus anticoagulant test result was positive, but he did not meet the criteria for antiphospholipid syndrome because he was negative for anticardiolipin and β

Indexed as

DyspneaEndarterectomyAnticoagulantsChest PainHumansMaleMiddle AgedAnticoagulants

Identifiers

PMID36344135
PMCPMC9808716
OpenAlexW4308637415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.