Evidence map›Paper›PMID 36344132›Full record

ArticleChest2022

A Case of Thrombotic Microangiopathy and Acute Sarcoidosis.

Anthony W Martinelli, William Dunn, Mark E McClure, Ieuan Walker, Andrew Stewart, Sumit Karia, Stephen D Preston, Sathia Thiru, Nicholas Torpey, Sanjay Ojha and 2 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Anthony W MartinelliDepartment of Respiratory Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, England; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, England. Electronic address: anthony.martinelli@nhs.net.
William DunnDepartment of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, England.
Mark E McClureDepartment of Renal Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, England.
Ieuan WalkerDepartment of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, England.
Andrew StewartDepartment of Renal Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, England.
Sumit KariaDepartment of Radiology, Addenbrooke's Hospital, Hills Road, Cambridge, England.
Stephen D PrestonDepartment of Histopathology, Royal Papworth Hospital, Cambridge, England.
Sathia ThiruDepartment of Histopathology, Addenbrooke's Hospital, Hills Road, Cambridge, England.
Nicholas TorpeyDepartment of Renal Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, England.
Sanjay OjhaDepartment of Renal Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, England.
Emily SymingtonDepartment of Haematology, Addenbrooke's Hospital, Hills Road, Cambridge, England.
James A NathanDepartment of Respiratory Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, England; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, England.
Addenbrooke's Hospital · GBCambridge School · PTPapworth Hospital · GB

Funding

Wellcome Trust 215477/Z/19/ZWellcome Trust 220535/Z/20/Z
6 · The paper itself

Abstract

Although sarcoidosis is an established cause of multiorgan dysfunction, acute presentation with thrombotic microangiopathy resulting in severe renal and hematological sequelae has not been reported. We describe the case of a patient presenting with hypercalcemia, pancreatitis, and acute renal failure, followed by microangiopathic hemolytic anemia. Although there were no significant respiratory symptoms, thoracic radiology and mediastinal lymph node biopsy results were in keeping with sarcoidosis as the underlying cause of this multisystem presentation. Corticosteroids were commenced with clinical and biochemical improvement. This novel case highlights the need to consider sarcoidosis as part of the differential diagnosis for unusual multiorgan presentations and for early multidisciplinary involvement in such cases to permit optimal treatment.

Indexed as

Acute Kidney InjurySarcoidosisThrombotic MicroangiopathiesBiopsyHumansKidneyHemolytic anemiaILDMAHAsarcoidosisthrombotic microangiopathyTMA

Identifiers

PMID36344132
PMCPMC9752182
OpenAlexW4308203943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.