Evidence map›Paper›PMID 36344005›Full record

ArticleBMJ open2022

Comparing restrictive versus liberal oxygen strategies for trauma patients - the TRAUMOX2 trial: protocol for a randomised clinical trial.

Josefine Baekgaard, Tobias Arleth, Volkert Siersma, Jochen Hinkelbein, Sirin Yücetepe, Markus Klimek, Mark G van Vledder, Esther M M Van Lieshout, Søren Mikkelsen, Stine Thorhauge Zwisler and 5 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05146700 (Comparing Restrictive Vs. Liberal Oxygen Strategies for Trauma Patients), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05146700 phase4completednot on this map

Comparing Restrictive Vs. Liberal Oxygen Strategies for Trauma Patients: the TRAUMOX2 Trial

TypeinterventionalSponsorRigshospitalet, DenmarkRan2021 to 2024Enrolled1,508ConditionsTrauma, Oxygen Toxicity, Wounds and InjuriesArmsRestrictive oxygen, Liberal oxygen
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Hypoxemia in trauma patients receiving two different oxygen strategies: a TRAUMOX2 substudy.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Josefine BaekgaardDepartment of Anaesthesia and Trauma Centre, Centre of Head and Orthopaedics, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark josefinebaekgaard@me.com.ORCID 0000-0002-5420-723X
Tobias ArlethDepartment of Anaesthesia and Trauma Centre, Centre of Head and Orthopaedics, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Volkert SiersmaThe Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Jochen HinkelbeinDepartment of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany.
Sirin YücetepeDepartment of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany.
Markus KlimekDepartment of Anaesthesiology, University Medical Centre Rotterdam, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands.ORCID 0000-0002-0122-9929
Mark G van VledderTrauma Research Unit Department of Surgery, University Medical Centre Rotterdam, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands.
Esther M M Van LieshoutTrauma Research Unit Department of Surgery, University Medical Centre Rotterdam, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands.ORCID 0000-0002-2597-7948
Søren MikkelsenThe Prehospital Research Unit, University of Southern Denmark, Odense, Syddanmark, Denmark.ORCID 0000-0002-5187-7027
Stine Thorhauge ZwislerThe Prehospital Research Unit, University of Southern Denmark, Odense, Syddanmark, Denmark.
Mikkel AndersenDepartment of Anaesthesiology, Aarhus University Hospital, Aarhus, Denmark.
Christian Fenger-EriksenDepartment of Anaesthesiology, Aarhus University Hospital, Aarhus, Denmark.
Dan L IsbyeDepartment of Anaesthesia and Trauma Centre, Centre of Head and Orthopaedics, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Lars S RasmussenDepartment of Anaesthesia and Trauma Centre, Centre of Head and Orthopaedics, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Jacob SteinmetzDepartment of Anaesthesia and Trauma Centre, Centre of Head and Orthopaedics, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
University of Copenhagen · DKErasmus MC · NLAarhus University Hospital · DKUniversity Hospital Cologne · DEUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSupplemental oxygen is commonly used in trauma patients, although it may lead to hyperoxaemia that has been associated with pulmonary complications and increased mortality. The primary objective of this trial, TRAUMOX2, is to compare a restrictive versus liberal oxygen strategy the first 8 hours following trauma. METHODS AND ANALYSIS: TRAUMOX2 is an investigator-initiated, international, parallel-grouped, superiority, outcome assessor-blinded and analyst-blinded, randomised, controlled, clinical trial.Adult patients with suspected major trauma are randomised to eight hours of a restrictive or liberal oxygen strategy. The restrictive group receives the lowest dosage of oxygen ( ETHICS AND DISSEMINATION: TRAUMOX2 is carried out in accordance with the Helsinki II Declaration. It has been approved by the Danish Committee on Health Research Ethics for the Capital Region (H-21018062) and The Danish Medicines Agency, as well as the Dutch Medical Research Ethics Committee Erasmus MS (NL79921.078.21 and MEC-2021-0932). A website (www.traumox2.org) is available for updates and study results will be published in an international peer-reviewed scientific journal. TRIAL REGISTRATION NUMBERS: EudraCT 2021-000556-19; NCT05146700.

Indexed as

COVID-19SARS-CoV-2AdultEquivalence Trials as TopicHumansOxygenRandomized Controlled Trials as TopicTreatment OutcomeOxygenAdult anaesthesiaAdult intensive & critical careRespiratory physiologyTRAUMA MANAGEMENT

Identifiers

PMID36344005
PMCPMC9644337
OpenAlexW4308435698

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.