Evidence map›Paper›PMID 36343965›Full record

ArticleAnalytical chemistry2022

Microscale Quantification of the Inhibition of Neuraminidase Using Capillary Nanogel Electrophoresis.

Laura D Casto-Boggess, Lisa A Holland, Paul A Lawer-Yolar, John A Lucas, Jessica R Guerrette

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. [Annual review of capillary electrophoresis technology in 2022].Se pu = Chinese journal of chromatography · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laura D Casto-BoggessC. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia26505, United States.ORCID 0000-0003-0493-4241
Lisa A HollandC. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia26505, United States.ORCID 0000-0002-7534-6810
Paul A Lawer-YolarC. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia26505, United States.
John A LucasC. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia26505, United States.
Jessica R GuerretteC. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia26505, United States.
West Virginia University · US

Funding

Enabling Technology to Screen and Quantify Sialylated Structures for Activity Against Viral Enzymes and ReceptorsR01GM140560 · NIGMS · WEST VIRGINIA UNIVERSITY · PI HOLLAND, LISA A · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM140560
6 · The paper itself

Abstract

Neuraminidase inhibitors modulate infections that involve sialic acids, making quantitative analyses of this inhibitory effect important for selecting and designing potential therapeutics. An automated nanogel capillary electrophoresis system is developed that integrates a 5 nL enzyme inhibition reaction in line with a 5 min separation-based assay of the enzymatic product to quantify inhibition as the half maximal inhibitory concentration (IC

Indexed as

Electrophoresis, CapillaryNeuraminidaseEnzyme InhibitorsNanogelsPolyethylene GlycolsPolyethyleneimineEnzyme InhibitorsNanogelsNeuraminidasepolyethylene glycol polyethyleneimine nanogelPolyethylene GlycolsPolyethyleneimine

Identifiers

PMID36343965
PMCPMC9686991
OpenAlexW4308384289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.