Evidence map›Paper›PMID 36343699›Full record

ArticleAmerican journal of ophthalmology2023

Impact of Ocular Conditions and Improvements After Refractive Surgery in Quality of Life for Children With Neurodevelopmental Disorders.

Alexandra Zdonczyk, Lawrence Tychsen, John N Constantino, Susan M Culican, Amer Al Badawi, Margaret Reynolds

Open access · greenAbstract read
In one paragraph

Article in American journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Association of primary congenital glaucoma with quality of life in children and their families.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. Article
  3. Visual Autism.Children (Basel, Switzerland) · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexandra ZdonczykFrom the Department of Ophthalmology & Visual Sciences (A.Z., L.T., A.A.B., M.R.), Washington University School of Medicine, St. Louis, Missouri, USA.
Lawrence TychsenFrom the Department of Ophthalmology & Visual Sciences (A.Z., L.T., A.A.B., M.R.), Washington University School of Medicine, St. Louis, Missouri, USA.
John N ConstantinoDepartment of Psychiatry (J.N.C.), Washington University School of Medicine, St. Louis, Missouri, USA.
Susan M CulicanDepartment of Ophthalmology and Visual Neurosciences (S.M.C.), University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Amer Al BadawiFrom the Department of Ophthalmology & Visual Sciences (A.Z., L.T., A.A.B., M.R.), Washington University School of Medicine, St. Louis, Missouri, USA.
Margaret ReynoldsFrom the Department of Ophthalmology & Visual Sciences (A.Z., L.T., A.A.B., M.R.), Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: margaret.reynolds@wustl.edu.
Washington University in St. Louis · USUniversity of Minnesota Medical Center · US

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Washington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5M
NCATS NIH HHS TL1 TR002344NICHD NIH HHS P50 HD103525
6 · The paper itself

Abstract

purposeThis study aims to characterize the eye-related quality of life of children with neurodevelopmental and ocular disorders at baseline and after refractive surgery.

designProspective interventional case series.

methodsWe enrolled children and adolescents 5 to 18 of age with neurodevelopmental disorders undergoing refractive surgery (6 for pre-/postsurgical assessment and 14 for baseline analysis). Eye-related quality of life was measured using the Pediatric Eye Questionnaire (PedEyeQ). Baseline levels of adaptive functioning and social behaviors were measured using the Adaptive Behavioral Assessment System (ABAS-3) and Social Responsiveness Scale (SRS-2). We assessed the correlation between baseline PedEyeQ scores, number of ocular comorbidities, magnitude of refractive error, and ABAS-3 and SRS-2 scores.

resultsAt baseline, 14 patients demonstrated decreased median eye-related quality of life (<60/100) in 5 of 9 PedEyeQ domains, moderate deficiencies in social behaviors (SRS-2 median 71, range 49-90), and low adaptive functioning (ABAS-3 median percentile for age of 0.100). Baseline PedEyeQ scores did not correlate with magnitude of refractive error or adaptive functioning scores but did correlate with number of ocular comorbidities and social behavior scores. Six patients have undergone refractive surgery without complication. Postoperatively, 11 of 11 eyes were within ±1.5 diopters spherical equivalent. Four of 6 patients exhibited clinically significant improvements in PedEyeQ scores after surgery.

conclusionsEven in the presence of significant social and adaptive impairments, quality of life in children with neurodevelopmental disorders is decreased by ocular disorders. Refractive surgery is associated with clinically significant improvements in eye-related quality of life.

Indexed as

Eye DiseasesNeurodevelopmental DisordersRefractive ErrorsRefractive Surgical ProceduresAdolescentChildHumansProspective StudiesQuality of LifeRefraction, OcularVisual Acuity

Identifiers

PMID36343699
PMCPMC11331587
OpenAlexW4308209461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.