Evidence map›Paper›PMID 36343686›Full record

ArticleChest2023

Consensus Statements on Deployment-Related Respiratory Disease, Inclusive of Constrictive Bronchiolitis: A Modified Delphi Study.

Michael J Falvo, Anays M Sotolongo, John J Osterholzer, Michelle W Robertson, Ella A Kazerooni, Judith K Amorosa, Eric Garshick, Kirk D Jones, Jeffrey R Galvin, Kathleen Kreiss and 10 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in Chest, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Postdeployment Respiratory Health: It's Not Always the Lungs.Annals of the American Thoracic Society · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 16 institutions in 1 country.

Michael J FalvoAirborne Hazards and Burn Pits Center of Excellence, Department of Veterans Affairs New Jersey Health Care System, East Orange, NJ; New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ. Electronic address: Michael.Falvo@va.gov.
Anays M SotolongoAirborne Hazards and Burn Pits Center of Excellence, Department of Veterans Affairs New Jersey Health Care System, East Orange, NJ; New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ.
John J OsterholzerPulmonary Section, Department of Medicine, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI; Division of Pulmonary and Critical Care, Department of Medicine, University of Michigan, Ann Arbor, MI.
Michelle W RobertsonAirborne Hazards and Burn Pits Center of Excellence, Department of Veterans Affairs New Jersey Health Care System, East Orange, NJ.
Ella A KazerooniDepartment of Radiology, University of Michigan, Ann Arbor, MI; Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Judith K AmorosaDepartment of Radiology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; University Radiology Group, East Brunswick, NJ.
Eric GarshickPulmonary, Allergy, Sleep, and Critical Care Medicine Section, Veterans Affairs Boston Healthcare System, Boston, MA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.
Kirk D JonesDepartment of Anatomic Pathology, University of California, San Francisco, CA.
Jeffrey R GalvinDepartment of Radiology and Nuclear Medicine (Chest Imaging), University of Maryland School of Medicine, Baltimore, MD.
Kathleen KreissRespiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV.
Stella E HinesDivisions of Occupational and Environmental Medicine and Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD; VA Maryland Health Care System, Baltimore Veterans Affairs Medical Center, Baltimore, MD.
Teri J FranksDepartment of Pulmonary and Mediastinal Pathology, Joint Pathology Center, Department of Defense, Silver Spring, MD.
Robert F MillerDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
Cecile S RoseDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Denver, CO.
Mehrdad ArjomandiDepartment of Anatomic Pathology, University of California, San Francisco, CA; Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA.
Silpa D KrefftDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO; Division of Pulmonary and Critical Care Medicine, Veterans Administration Eastern Colorado Health Care System, Aurora, CO; Division of Pulmonary and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO.
Michael J MorrisPulmonary/Critical Care Service, Department of Medicine, Brooke Army Medical Center, JBSA-Sam Houston, Fort Sam Houston, TX.
Vasiliy V PolosukhinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Paul D BlancDepartment of Anatomic Pathology, University of California, San Francisco, CA; Division of Occupational and Environmental Medicine, University of California, San Francisco, CA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Jeanine M D'ArmientoCenter for LAM and Rare Lung Disease, Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY.
Vanderbilt University Medical Center · USRutgers New Jersey Medical SchoolBrigham and Women's Hospital · USColumbia University · USNational Institute for Occupational Safety and Health · USNational Jewish Health · USSan Antonio Military Medical Center · USSan Francisco VA Medical Center · USUnited States Department of Defense · USUniversity of California, San Francisco · USUniversity of Colorado Denver · USUniversity of Maryland, Baltimore · USUniversity of Michigan–Ann Arbor · USUniversity Radiology · USVA Ann Arbor Healthcare System · USVA Maryland Health Care System · US

Funding

Targeted Research Training CoreT42OH008429 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS ADAMSON, CARISA · 2005 to 2024
$30.0M
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of DiseaseUH3HL152323 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ARMIENTO, JEANINE M, STRANGE, CHARLTON B · 2022 to 2025
$4.3M
CMA: Pulmonary and Systemic Effects of Deployment Related Particulate Matter ExposuresI01BX004619 · VA · VA BOSTON HEALTH CARE SYSTEM · PI ERIC GARSHICK · 2020 to 2026
–
Clinical Markers and Monitoring for Post-9-11 Deployment Lung DiseasesIK2CX001779 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Silpa Dhoma Krefft · 2020 to 2026
–
BLRD VA I01 BX004619CSRD VA IK2 CX001779NHLBI NIH HHS UH3 HL152323NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

backgroundThe diagnosis of constrictive bronchiolitis (CB) in previously deployed individuals, and evaluation of respiratory symptoms more broadly, presents considerable challenges, including using consistent histopathologic criteria and clinical assessments. RESEARCH QUESTION: What are the recommended diagnostic workup and associated terminology of respiratory symptoms in previously deployed individuals? STUDY DESIGN AND

methodsNineteen experts participated in a three-round modified Delphi study, ranking their level of agreement for each statement with an a priori definition of consensus. Additionally, rank-order voting on the recommended diagnostic approach and terminology was performed.

resultsTwenty-five of 28 statements reached consensus, including the definition of CB as a histologic pattern of lung injury that occurs in some previously deployed individuals while recognizing the importance of considering alternative diagnoses. Consensus statements also identified a diagnostic approach for the previously deployed individual with respiratory symptoms, distinguishing assessments best performed at a local or specialty referral center. Also, deployment-related respiratory disease (DRRD) was proposed as a broad term to subsume a wide range of potential syndromes and conditions identified through noninvasive evaluation or when surgical lung biopsy reveals evidence of multicompartmental lung injury that may include CB.

interpretationUsing a modified Delphi technique, consensus statements provide a clinical approach to possible CB in previously deployed individuals. Use of DRRD provides a broad descriptor encompassing a range of postdeployment respiratory findings. Additional follow-up of individuals with DRRD is needed to assess disease progression and to define other features of its natural history, which could inform physicians better and lead to evolution in this nosology.

Indexed as

Bronchiolitis ObliteransLung InjuryRespiration DisordersRespiratory Tract DiseasesDelphi TechniqueEye Diseases, HereditaryHumansRetinal DetachmentbronchiolitisDelphi techniquedyspneaenvironmental exposuremilitary deployment

Identifiers

PMID36343686
PMCPMC10154857
OpenAlexW4308551220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.