ArticleEnvironment international2022
Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater.
Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 49 citations in OpenAlex.
- Effect-Based Assessment of the Quality and Potential Presence of Hazardous Chemical Pollutants in Drinking and Potable Water in Mexico City.ACS ES&T water · 2026Article
- Human and zebrafish mineralocorticoid receptors reporter cell assays to assess the activity of chemicals.iScience · 2025Article
- Following the Mixtures of Organic Micropollutants withACS environmental Au · 2025Article
- Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification - is it time for HT-EDA?Analytical and bioanalytical chemistry · 2025Review
- Transforming the interrelated nature of human psychoneuroendocrine health and endocrine disrupting compounds in our planet's water: from Wilhelm Waldeyer's neuron theory to an artificial intelligence extension of the human body?Frontiers in medicine · 2025Review
- A Microbial Cocaine Bioreporter.Sensors (Basel, Switzerland) · 2024Article
- Predicting the Combined Effects of Multiple Stressors and Stress Adaptation inEnvironmental science & technology · 2024Article
- Wrangling Whole Mixtures Risk Assessment: Recent Advances in Determining Sufficient Similarity.Current opinion in toxicology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study on endocrine disrupting chemicals (EDCs) in treated wastewater, we used chemical and effect-based tools to analyse 56 wastewater treatment plant (WWTP) effluents from 15 European countries. The main objectives were (i) to compare three different receptor-based estrogenicity assays (ERα-GeneBLAzer, p-YES, ERα-CALUX®), and (ii) to investigate a combined approach of chemical target analysis and receptor-based testing for estrogenicity, glucocorticogenic activity, androgenicity and progestagenic activity (ERα-, GR-, AR- and PR-GeneBLAzer assays, respectively) in treated wastewater. A total of 56 steroids and phenols were detected at concentrations ranging from 25 pg/L (estriol, E3) up to 2.4 μg/L (cortisone). WWTP effluents, which passed an advanced treatment via ozonation or via activated carbon, were found to be less contaminated, in terms of lower or no detection of steroids and phenols, as well as hormone receptor-mediated effects. This result was confirmed by the effect screening, including the three ERα-bioassays. In the GeneBLAzer assays, ERα-activity was detected in 82 %, and GR-activity in 73 % of the samples, while AR- and PR-activity were only measured in 14 % and 21 % of the samples, respectively. 17β-estradiol was confirmed as the estrogen dominating the observed estrogenic mixture effect and triamcinolone acetonide was the dominant driver of glucocorticogenic activity. The comparison of bioanalytical equivalent concentrations (BEQ) predicted from the detected concentrations and the relative effect potency (BEQ
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