Evidence map›Paper›PMID 36343510›Full record

ArticlePregnancy hypertension2022

Sleep disordered breathing and the risk of severe maternal morbidity in women with preeclampsia: A population-based study.

Isabelle Malhamé, Margaret H Bublitz, Danielle Wilson, Laura Sanapo, Elizabeth Rochin, Ghada Bourjeily

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pregnancy hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Isabelle MalhaméDepartment of Medicine, McGill University Health Centre, Montreal, Canada; Research Institute of the McGill University Health Centre, Montreal, Canada.
Margaret H BublitzPsychiatry and Human Behavior and Medicine, The Miriam Hospital, Warren Alpert Medical School of Brown University, Providence, RI, United States.
Danielle WilsonInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia.
Laura SanapoPsychiatry and Human Behavior and Medicine, The Miriam Hospital, Warren Alpert Medical School of Brown University, Providence, RI, United States.
Elizabeth RochinNational Perinatal Information Center, Providence, RI, United States.
Ghada BourjeilyPsychiatry and Human Behavior and Medicine, The Miriam Hospital, Warren Alpert Medical School of Brown University, Providence, RI, United States. Electronic address: Ghada_Bourjeily@brown.edu.
Brown University · USInstitute for Breathing and Sleep · AUMcGill University Health Centre · CAProvidence College · US

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV, HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Mechanisms of mindfulness training to prevent hypertensive disorders of pregnancyR01HL157288 · NHLBI · MIRIAM HOSPITAL · PI BUBLITZ, MARGARET · 2021 to 2025
$2.8M
Placental role in mediating adverse outcomes in obstructive sleep apneaR01HD078515 · NICHD · MIRIAM HOSPITAL · PI BOURJEILY, GHADA · 2014 to 2018
$2.7M
Predictors of de novo development of obstructive sleep apnea in pregnancyR01HL130702 · NHLBI · MIRIAM HOSPITAL · PI BOURJEILY, GHADA · 2016 to 2020
$2.6M
NHLBI NIH HHS R01 HL130702NHLBI NIH HHS R01 HL157288NICHD NIH HHS R01 HD078515NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

objectiveObstructive sleep apnea (OSA) may exacerbate the widespread endothelial dysfunction seen in preeclampsia, potentially worsening clinical outcomes. We aimed to assess whether OSA is associated with an increased risk of severe maternal morbidity, cardiovascular morbidity, and healthcare utilization among women with preeclampsia. STUDY

designWe performed a retrospective cohort study utilizing data from the National Perinatal Information Center (2010-2014) in the United States.The cohort comprised women with preeclampsia. We estimated the association between OSA and the outcomes using logistic regression analyses and determined odds ratio adjusted for demographic factors and comorbidities (OR

main outcome measuresThe primary outcome was a composite of mortality and severe maternal morbidity comprising intensive care unit (ICU) admission, acute renal failure, pulmonary edema, pulmonary embolism, congestive heart failure, cardiomyopathy, and stroke. Secondary outcomes comprised the subset of cardiovascular events, as well as increased healthcare utilization (including Cesarean delivery, preterm birth, ICU admission, and prolonged length of hospital stay).

resultsIn total, 71,159 women had preeclampsia, including 270 (0.4 %) with OSA. Women with preeclampsia and OSA were more likely to experience severe maternal morbidity than women without OSA (OR

conclusionIn women with preeclampsia, OSA increases the risk for severe maternal morbidity, cardiovascular morbidity, and healthcare utilization.

Indexed as

CardiomyopathiesPre-EclampsiaPremature BirthSleep Apnea, ObstructiveSleep Apnea SyndromesFemaleHumansInfant, NewbornPregnancyRetrospective StudiesUnited StatesMaternal morbidityObstructive sleep apneaOSAPeripartumPostpartumPreeclampsiaPregnancySleep disordered breathing

Identifiers

PMID36343510
PMCPMC9712248
OpenAlexW4308152468

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.