Evidence map›Paper›PMID 36343449›Full record

ArticleEcotoxicology and environmental safety2022

Deficiency of interleukin-6 receptor ameliorates PM

Renzhen Peng, Wenhui Yang, Wenpu Shao, Bin Pan, Yaning Zhu, Yubin Zhang, Haidong Kan, Yanyi Xu, Zhekang Ying

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ecotoxicology and environmental safety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. PMArchives of toxicology · 2026
    Article
  2. Article
  3. Gut microbiota mediates ambient PMJournal of hazardous materials · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renzhen PengDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Wenhui YangDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Wenpu ShaoDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Bin PanDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Yaning ZhuDepartment of Pathology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Yubin ZhangDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Haidong KanDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Yanyi XuDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, China. Electronic address: yanyi_xu@fudan.edu.cn.
Zhekang YingDepartment of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: yingzhekang@hotmail.com.

Funding

Mechanism for Programming of Offspring Adiposity by Maternal PM2.5 ExposureR01ES032290 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI YING, ZHEKANG, YU, LIQING · 2021 to 2025
$3.1M
Hypothalamic Inflammation and PM2.5 Exposure-Induced Insulin ResistanceR01ES024516 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI YING, ZHEKANG · 2014 to 2018
$1.5M
NIEHS NIH HHS R01 ES024516NIEHS NIH HHS R01 ES032290
6 · The paper itself

Abstract

backgroundAmbient fine particulate matter (PM

resultsIn the study, IL-6 receptor (IL-6R)-deficient (IL-6R

conclusionOur findings support the crucial role of IL-6 signalling in the development of pulmonary inflammation and dysfunction due to PM

Indexed as

Insulin ResistanceInterleukin-6AnimalsGlucoseHomeostasisInflammationMiceParticulate MatterReceptors, Interleukin-6GlucoseInterleukin-6Particulate MatterReceptors, Interleukin-6Glucose homeostasisIL-6RInflammationPM(2.5)Pulmonary dysfunction

Identifiers

PMID36343449
PMCPMC9759823

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.