Evidence map›Paper›PMID 36343429›Full record

ArticleEuropean journal of medicinal chemistry2022

From rational design to serendipity: Discovery of novel thiosemicarbazones as potent trypanocidal compounds.

Saulo Fehelberg Pinto Braga, Viviane Corrêa Santos, Rafael Pinto Vieira, Elany Barbosa da Silva, Ludovica Monti, Susann H Krake, Pablo D G Martinez, Luiz Carlos Dias, Conor R Caffrey, Jair L Siqueira-Neto and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Desulfurization of thiosemicarbazones: the role of metal ions and biological implications.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Saulo Fehelberg Pinto BragaDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil; Department of Pharmacy, School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, 35400-000, Minas Gerais, Brazil. Electronic address: saulo.braga@ufop.edu.br.
Viviane Corrêa SantosDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil.
Rafael Pinto VieiraDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil.
Elany Barbosa da SilvaCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0657, USA.
Ludovica MontiCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0657, USA.
Susann H KrakeInstitute of Chemistry, Department of Organic Chemistry, Campinas State University, Cidade Universitária Zeferino Vaz, CP 6154, Campinas, 13083-970, São Paulo, Brazil.
Pablo D G MartinezInstitute of Chemistry, Department of Organic Chemistry, Campinas State University, Cidade Universitária Zeferino Vaz, CP 6154, Campinas, 13083-970, São Paulo, Brazil.
Luiz Carlos DiasInstitute of Chemistry, Department of Organic Chemistry, Campinas State University, Cidade Universitária Zeferino Vaz, CP 6154, Campinas, 13083-970, São Paulo, Brazil.
Conor R CaffreyCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0657, USA.
Jair L Siqueira-NetoCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0657, USA.
Renata Barbosa de OliveiraDepartment of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, 31270-901, MG, Brazil.
Rafaela Salgado FerreiraDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil. Electronic address: rafaelasf@icb.ufmg.br.
Universidade Federal de Minas Gerais · BRUniversity of Montana · USUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Ouro Preto · BR

Funding

Brain Penetrant Microtubule-Stabilizers to Treat CNS-invasive Parasitic DiseasesR21AI141210 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BALLATORE, CARLO, CAFFREY, CONOR · 2019 to 2020
$441k
NIAID NIH HHS R21 AI141210
6 · The paper itself

Abstract

Chagas disease is a major public health problem caused by Trypanosoma cruzi, with an estimated 6-7 million people infected and 70 million at risk of infection. T. brucei gambiense and T. brucei rhodesiense are two subspecies of related parasites that cause human African trypanosomiasis, a neglected tropical disease with also millions of people at risk of infection. Pharmacotherapy for both diseases suffers from low efficacy, side effects, or drug resistance. Recently, we reported a noncovalent competitive inhibitor of cruzain (IC

Indexed as

Chagas DiseaseThiosemicarbazonesTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosoma cruziCysteine Proteinase InhibitorsHumansStructure-Activity RelationshipCysteine Proteinase InhibitorsThiosemicarbazonesTrypanocidal AgentsCruzainTbrCatL (rhodesain)ThiosemicarbazoneTrypanosoma bruceiTrypanosoma cruzi

Identifiers

PMID36343429
PMCPMC13124246
OpenAlexW4308360243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.