Evidence map›Paper›PMID 36343245›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms.

Irene Y Y Szeto, Daniel K H Chu, Peikai Chen, Ka Chi Chu, Tiffany Y K Au, Keith K H Leung, Yong-Heng Huang, Sarah L Wynn, Angel C Y Mak, Ying-Shing Chan and 6 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. A Systematic Review of Genes Affecting Endocochlear Potential.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Combined AAV-mediated specific Gjb2 expression restores hearing in DFNB1 mouse models.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  7. [Mechanisms of enhanced noise susceptibility in waardenburg syndromeLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  8. Cochlear Implantation Outcomes in Genotyped Subjects with Sensorineural Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Frontiers in cell and developmental biology · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Methods for studying mammalian aquaporin biology.Biology methods & protocols · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 4 countries.

Irene Y Y SzetoSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0002-3925-1136
Daniel K H ChuSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0001-6825-5884
Peikai ChenSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0003-1880-0893
Ka Chi ChuSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0003-3914-2412
Tiffany Y K AuSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0002-4131-1951
Keith K H LeungSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0002-8960-3937
Yong-Heng HuangGenome Regulation Laboratory, CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Sarah L WynnSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0001-6531-8181
Angel C Y MakSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0002-5372-4198
Ying-Shing ChanSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.
Wood Yee ChanSchool of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0000-0002-7114-1463
Ralf JauchSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0002-6590-9579
Bernd FritzschDepartment of Biology, College of Arts & Sciences, University of Iowa, Iowa City, IA 52242.ORCID 0000-0002-4882-8398
Mai Har ShamSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0003-1179-7839
Robin Lovell-BadgeFrancis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0001-9364-4179
Kathryn S E CheahSchool of Biomedical Sciences, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China.ORCID 0000-0003-0802-8799
Chinese University of Hong Kong · HKChinese Academy of Sciences · CNThe Francis Crick Institute · GBUniversity of Iowa · US

Funding

Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
Medical Research Council MC_U117562207NIA NIH HHS R01 AG060504
6 · The paper itself

Abstract

The in vivo mechanisms underlying dominant syndromes caused by mutations in SRY-Box Transcription Factor 9 (

Indexed as

DeafnessEar, InnerSOX9 Transcription FactorSOXE Transcription FactorsAnimalsHearingHomeostasisMiceMice, KnockoutSox10 protein, mouseSox9 protein, mouseSOX9 Transcription FactorSOXE Transcription Factorsdevelopmental syndromedominant negativehaploinsufficiencyinner ear endolymphatic systemSOXE transcription factors

Identifiers

PMID36343245
PMCPMC9674217
OpenAlexW4308430104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.