ArticleJournal of neuropathology and experimental neurology2022
Postmortem 7T MRI for guided histopathology and evaluation of cerebrovascular disease.
Article in Journal of neuropathology and experimental neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- An open-source stereotaxic container with an integrated cutting guide for human brain fixation during magnetic resonance imaging and sectioning for histology.bioRxiv : the preprint server for biology · 2026Article
- A pipeline to characterize spinal cord pathology in neurological disorders combining magnetic resonance microscopy and histopathology.Communications medicine · 2026Article
- Operationalizing postmortem pathology-MRI association studies in Alzheimer's disease and related disorders with MRI-guided histology sampling.Acta neuropathologica communications · 2025Article
- Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer's disease and related neurodegenerative pathologies using 7T postmortem MRI.Journal of neuropathology and experimental neurology · 2025Article
- Towards MRI Study of Biointegration of Carbon-Carbon Composites with Ca-P Coatings.Nanomaterials (Basel, Switzerland) · 2025Article
- Are white matter hyperintensities associated with neuroborreliosis? The answer is twofold.Neuroradiology · 2025Article
- Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Comparative Study of Postmortem MRI and Pathological Findings in Malignant Brain Tumors.Cureus · 2024Article
- Bridging Neuroimaging and Neuropathology: A Comprehensive Workflow for Targeted Sampling of White Matter Lesions.Journal of neuroimaging : official journal of the American Society of NeuroimagingReview
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Authors and funding
11 authors.
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Abstract
Postmortem (PM) magnetic resonance imaging (MRI) can serve as a bridge between in vivo imaging and histology by connecting MRI observed macrostructural findings to histological staining and microstructural changes. Data were acquired from 20 formalin-fixed brains including T2, T1, PD, and T2*-weighted images of left hemispheres and 6-mm-thick coronal slices. Tissue slices were bisected, aligned to MR images and used to guide histological sampling. Markers of myelin and oligodendroglia alterations were semiquantitatively rated and compared within white matter hyperintensities (WMHs) and normal-appearing white matter. Tissue priors were created from 3T in vivo data and used to guide segmentation of WMH. PM WMH and hemisphere volumes were compared to volumes derived from in vivo data. PM T2 WMH and T1 hemisphere volumes were correlated with in vivo 3T FLAIR WMH and T1 hemisphere volumes. WMH showed significant myelin loss, decreased GFAP expression and increased vimentin expression. MR-visible perivascular spaces and cortical microvascular lesions were successfully captured on histopathological sections. PM MRI can quantify cerebrovascular disease burden and guide tissue sampling, allowing for more comprehensive characterization of cerebrovascular disease that may be used to study etiologies of age-related cognitive change.
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