ArticleInternational journal of epidemiology2023
Childhood socio-economic circumstances and dementia: prospective register-based cohort study of adulthood socio-economic and cardiovascular health mediators.
Article in International journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review of the association between life-course socioeconomic status and late-life cognitive decline.Journal of epidemiology and community health · 2026Pooled it
- Multimorbidity and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Cognitive impairment and dementia-Are they linked to childhood health and socioeconomic status? A systematic review.PloS one · 2025Pooled it
- Association of Early Life Risk Factors and APOE ε4 With Incident Dementia: Evidence From 14 Years of U.S. Data.Journal of the American Geriatrics Society · 2025Article
- Personality as mechanism: An integrative model of five-factor model personality traits as a mechanism between earlier life factors and cognitive aging.Current opinion in psychology · 2025Review
- Social determinants of dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Down syndrome in Africa: Challenges, opportunities, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes.Neurology · 2025Article
- Gender and Educational Trends in Lifetime Risk, Age at Onset, Expectancy, and Survival With Cardiovascular Disease in Finland, 1996-2020.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- The relationship between vitamin D levels and Alzheimer's disease risk: insights from a centenarian study of Chinese women.Frontiers in nutrition · 2025Article
- Sex Differences for Social Determinants Associated with Lewy Body Dementia Onset and Diagnosis.Neuro-degenerative diseases · 2025Article
- Inequalities in overcrowding in households with children in an ethnically diverse urban population: a cross-sectional study using linked health and housing records.International journal of population data science · 2025Article
- Role of cardiovascular health factors in mediating social inequalities in the incidence of dementia in the UK: two prospective, population-based cohort studies.EClinicalMedicine · 2024Article
- Air pollution, dementia, and lifespan in the socio-economic gradient of aging: perspective on human aging for planning future experimental studies.Frontiers in aging · 2023Article
- Sexual Orientation Disparities in Subjective Cognitive Decline in a Large Cohort of Female Nurses.LGBT healthArticle
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5 authors.
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Abstract
backgroundThis study analysed the association between childhood socio-economic circumstances and the risk of dementia, and investigated the mediating role of potentially modifiable risk factors including adulthood socio-economic position and cardiovascular health.
methodsWe used a 10% sample of the 1950 Finnish population census linked with subsequent population and health registers (n = 95 381). Information of socio-economic characteristics, family structure and housing conditions at the age of 0-15 years was obtained from the 1950 census. We identified cohort members who developed dementia in 2000-2018 using national hospital, medication and death registers. Discrete time survival analysis using logistic regression and mediation analysis applying the Karlson-Holm-Breen (KHB) method were employed.
resultsAn excess risk of dementia was observed for household crowding [odds ratio (OR) = 1.10; 95% CI 1.02-1.18 for 3 to <4 persons per heated room; OR = 1.19; 95% CI 1.11-1.27 for ≥4 persons], single-father family (OR = 1.27; 95% CI 1.07-1.51) and eastern and northern region of residence (OR = 1.19; 95% CI 1.10-1.28). The effects of single-father family and region of residence were mostly direct with adulthood characteristics mediating 14% and 29% of the total effect, respectively. The largest indirect effect was observed for household crowding mediated through adulthood socio-economic position (47-65%).
conclusionsThe study shows that childhood socio-economic circumstances are associated with dementia, and that the underlying mechanisms only partly relate to adulthood socio-economic position and cardiovascular health. Socio-economic and health interventions targeted at families with children may carry long-term benefits by contributing to a lower dementia risk in later life.
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