Evidence map›Paper›PMID 36342840›Full record

ArticleeLife2022

Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus.

Rachana Deven Somaiya, Katelyn Stebbins, Ellen C Gingrich, Hehuang Xie, John N Campbell, A Denise R Garcia, Michael A Fox

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Thalamic Activity Regulates Interneuron Density in the Developing Visual Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Primary cilia and neural computation.Journal of biomedical science · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rachana Deven SomaiyaCenter for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, United States.ORCID 0000-0002-1190-1192
Katelyn StebbinsCenter for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, United States.
Ellen C GingrichDepartment of Biology, Drexel University, Philadelphia, United States.
Hehuang XieFralin Life Sciences Institute at Virginia Tech, Blacksburg, United States.
John N CampbellDepartment of Biology, University of Virginia, Charlottesville, United States.
A Denise R GarciaDepartment of Biology, Drexel University, Philadelphia, United States.ORCID 0000-0001-5809-3543
Michael A FoxCenter for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, United States.ORCID 0000-0002-1649-7782
Biomedical Research Institute · USDrexel University · USVirginia College · USUniversity of Virginia · US

Funding

Regulation of nuclei-specific retinogeniculate targetingR01EY021222 · NEI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI FOX, MICHAEL A · 2011 to 2021
$3.8M
The role of Sonic hedgehog signaling on astrocyte function in the adult CNSR01NS096100 · NINDS · DREXEL UNIVERSITY · PI Anna Denise Resurreccion Garcia · 2016 to 2026
$3.6M
Molecular and Functional Taxonomy of Cardiovagal NeuronsR01HL153916 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAMPBELL, JOHN NELSON · 2021 to 2025
$3.1M
Retinal inputs signal through astrocytes to recruit interneurons into visual thalamusR21EY030568 · NEI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI FOX, MICHAEL A · 2019 to 2020
$443k
Identification of cell-type specific visual circuits in the ventral lateral geniculate nucleusR21EY033528 · NEI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CAMPBELL, JOHN N, FOX, MICHAEL A · 2022 to 2023
$441k
NEI NIH HHS R01 EY021222NEI NIH HHS R21 EY030568NEI NIH HHS R21 EY033528NHLBI NIH HHS R01 HL153916NINDS NIH HHS R01 NS096100
6 · The paper itself

Abstract

Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth factor 15 (FGF15), a motogen required for GABAergic interneuron migration into visual thalamus. However, how retinal axons induce thalamic astrocytes to generate

Indexed as

Hedgehog ProteinsInterneuronsAnimalsAxonsMiceRetinal Ganglion CellsThalamusHedgehog Proteinsactivityastrocytesinterneuronmouseneuroscienceretinal ganglion cellsonic hedgehogthalamus

Identifiers

PMID36342840
PMCPMC9640189
OpenAlexW4308387156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.