Evidence map›Paper›PMID 36342517›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023

The role of elective neck dissection in T1 and T2 nasal cavity squamous cell carcinomas.

Claudia Lill, Boban M Erovic, Rudolf Seemann, Muhammad Faisal, Klaus Stelter, Bernd Gandler, Florian Frommlet, Andreas Strobl, Michael Formanek, Stefan Janik

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. What is the rate of occult nodal metastasis in squamous cell carcinomas of the sinonasal tract? A systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Claudia LillInstitute of Head and Neck Diseases, Evangelical Hospital, Vienna, Austria.ORCID http://orcid.org/0000-0002-8822-4118
Boban M ErovicInstitute of Head and Neck Diseases, Evangelical Hospital, Vienna, Austria.
Rudolf SeemannInstitute of Head and Neck Diseases, Evangelical Hospital, Vienna, Austria.
Muhammad FaisalInstitute of Head and Neck Diseases, Evangelical Hospital, Vienna, Austria.
Klaus StelterENT-Centre Mangfall-Inn, Rosenheim, Germany.
Bernd GandlerDepartment of Otorhinolaryngology, Head and Neck Surgery, Clinic Klagenfurt, Klagenfurt, Austria.
Florian FrommletCenter for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
Andreas StroblDepartment of Otorhinolaryngology, Head and Neck Surgery, Ordensklinikum Linz, Linz, Austria.
Michael FormanekDepartment of Otorhinolaryngology and Phonetics, Hospital of St. John of God, Vienna, Austria.
Stefan JanikDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. stefan.janik@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-1161-4871
Medical University of Vienna · ATKepler Universitätsklinikum · ATSigmund Freud Privatuniversität Wien · ATUniversity of Klagenfurt · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the role of elective neck dissection (END) on oncological outcome in early-stage nasal cavity squamous cell carcinomas (SCCs).

methodsIn total, 87 patients with T1 (n = 59; 67.8%) and T2 (n = 28; 32.2%) SCCs were evaluated regarding performance of END, regional recurrences (RR) and its impact on cancer-specific survival (CSS). We further created a risk score based on T-classification, tumor subsite and grading to identify patients whom may benefit from END and calculated the corresponding numbers needed to treat (NNT) to prevent RR.

resultsNine (10.3%) patients experienced RR of whom 3 (5.1%) were T1 and 6 (21.4%) T2 tumors (p = 0.042). All RR originated from moderately or poorly differentiated (G2-G3) SCCs of the nasal septum or vestibule. END was done in 15 (17.2%) patients and none of those experienced RR (p = 0.121). Onset of RR represented the worst prognostic factor for CSS (HR 23.3; p = 0.007) with a 5y-CSS of 44.4% vs. 97.3% (p < 0.001). RR occurred in none of the patients with no or low risk scores compared to 31.6% (6/19) in patients with high-risk scores (p = 0.006). Accordingly, three high-risk patients would need to undergo END (NNT 2.63) to prevent RR compared to a NNT of 8 for the whole cohort.

conclusionsAlthough rare, occurrence of RR significantly deteriorates outcome in early stage nasal cavity SCCs, which could be effectively reduced by performance of END. The importance of END is currently underestimated and our proposed risk score helps identifying those patients who will benefit from END.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsHumansNasal CavityNeck DissectionNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesSquamous Cell Carcinoma of Head and NeckEarly-stage sinonasal carcinomaElective neck dissectionNasal cavity squamous cell carcinomaRegional recurrenceRisk score

Identifiers

PMID36342517
PMCPMC9988772
OpenAlexW4308368576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.