Evidence map›Paper›PMID 36342465›Full record

ArticleeLife2022

Contrasting effects of

Gustavo A Gomez, Charles H Rundle, Weirong Xing, Chandrasekhar Kesavan, Sheila Pourteymoor, Robert E Lewis, David R Powell, Subburaman Mohan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Obese-diabetic femaleJBMR plus · 2025
    Article
  3. Identification ofGenes · 2024
    Article
  4. KSR1 Knockout Mouse Model Demonstrates MAPK Pathway's Key Role in Cisplatin- and Noise-induced Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Gustavo A GomezVA Loma Linda Healthcare System, Loma Linda, United States.ORCID 0000-0001-9294-4276
Charles H RundleVA Loma Linda Healthcare System, Loma Linda, United States.
Weirong XingVA Loma Linda Healthcare System, Loma Linda, United States.
Chandrasekhar KesavanVA Loma Linda Healthcare System, Loma Linda, United States.
Sheila PourteymoorVA Loma Linda Healthcare System, Loma Linda, United States.
Robert E LewisUniversity of Nebraska Medical Center, Omaha, United States.ORCID 0000-0002-3616-2971
David R PowellLexicon Pharmaceuticals, The Woodlands, United States.ORCID 0000-0003-0656-0124
Subburaman MohanVA Loma Linda Healthcare System, Loma Linda, United States.ORCID 0000-0003-0063-986X
Loma Linda University Medical Center · USVA Loma Linda Healthcare System · USLexicon Pharmaceuticals (United States) · USUniversity of Nebraska Medical Center · US

Funding

Transgenic Approaches to Evaluate IGF-I Role in Peak BMDR01AR048139 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH &EDUC · PI MOHAN, SUBBURAMAN · 2003 to 2025
$4.7M
Thyroid hormone receptor β1 agonist therapy for the treatment of bone marrow adiposity in aging and obesityR21AG062866 · NIA · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI MOHAN, SUBBURAMAN · 2020 to 2021
$403k
Development of 3D Printed Synthetic Bone Graft Containing Small Molecules for Sequential Activation of Hedgehog and Hypoxia Signaling for Treatment of Nonunion FracturesI01BX005263 · VA · VA LOMA LINDA HEALTHCARE SYSTEM · PI SUBBURAMAN MOHAN · 2021 to 2026
–
BLRD Research Career Scientist Award ApplicationIK6BX005381 · VA · VA LOMA LINDA HEALTHCARE SYSTEM · PI SUBBURAMAN MOHAN · 2021 to 2026
–
BLRD VA I01 BX005263BLRD VA IK6 BX005381NIAMS NIH HHS R01 AR048139NIA NIH HHS R21 AG062866
6 · The paper itself

Abstract

Pathological obesity and its complications are associated with an increased propensity for bone fractures. Humans with certain genetic polymorphisms at the kinase suppressor of ras2 (KSR2) locus develop severe early-onset obesity and type 2 diabetes. Both conditions are phenocopied in mice with

Indexed as

AdiposityBone MarrowCancellous BoneAnimalsDiabetes Mellitus, Type 2HumansMiceMice, KnockoutObesityOsteoblastsProtein Serine-Threonine KinasesKSR2 protein, mouseProtein Serine-Threonine Kinasesadipose tissuegeneticsgenomicsmousemouse modelsosteoporosis

Identifiers

PMID36342465
PMCPMC9640193
OpenAlexW4308390347

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.