Evidence map›Paper›PMID 36342299›Full record

ArticleJournal of virology2022

Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids.

Luis Alberto Casorla-Perez, Ranya Guennoun, Ciro Cubillas, Bo Peng, Kerry Kornfeld, David Wang

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Luis Alberto Casorla-PerezDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-4643-2525
Ranya GuennounDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Ciro CubillasDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Bo PengDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Kerry KornfeldDevelopmental Biology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
David WangDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-0827-196X
Washington University in St. Louis · US

Funding

NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
TRANSCRIPTIONAL REGULATION OF ZINC HOMEOSTASISR01GM068598 · NIGMS · WASHINGTON UNIVERSITY · PI KORNFELD, KERRY · 2003 to 2025
$5.3M
DEFINING NOVEL, EVOLUTIONARILY CONSERVED HOST FACTORS CRITICAL FOR VIRUS INFECTION.R01AI134967 · NIAID · WASHINGTON UNIVERSITY · PI WANG, DAVID · 2018 to 2022
$2.0M
NIAID NIH HHS R01 AI134967NIGMS NIH HHS R01 GM068598NIGMS NIH HHS T32 GM007200
6 · The paper itself

Abstract

Viruses utilize host lipids to promote the viral life cycle, but much remains unknown as to how this is regulated. Zinc is a critical element for life, and few studies have linked zinc to lipid homeostasis. We demonstrated that Caenorhabditis elegans infection by Orsay virus is dependent upon lipids and that mutation of the master regulator of lipid biosynthesis,

Indexed as

Caenorhabditis elegans ProteinsNodaviridaeVirus DiseasesVirusesAnimalsCaenorhabditis elegansHumansLipidsMammalsRNA, ViralZincCaenorhabditis elegans ProteinsLipidsRNA, ViralZincCaenorhabditis eleganslipid regulationOrsay virusreplicationsbp-1/srebp-1zinc

Identifiers

PMID36342299
PMCPMC9682997
OpenAlexW4308370246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.