Evidence map›Paper›PMID 36342296›Full record

ArticleJournal of virology2022

The Origin of Internal Genes Contributes to the Replication and Transmission Fitness of H7N9 Avian Influenza Virus.

Joe James, Sushant Bhat, Sarah K Walsh, Thusitha K Karunarathna, Jean-Remy Sadeyen, Pengxiang Chang, Joshua E Sealy, Sahar Mahmood, Benjamin C Mollett, Marek J Slomka and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Joe James *Animal and Plant Health Agency, Weybridge, United Kingdom.ORCID 0000-0002-9673-3684
Sushant Bhat *Avian Influenza Group, The Pirbright Institute, Woking, United Kingdom.ORCID 0000-0003-1869-6176
Sarah K WalshAnimal and Plant Health Agency, Weybridge, United Kingdom.
Thusitha K KarunarathnaAvian Influenza Group, The Pirbright Institute, Woking, United Kingdom.
Jean-Remy SadeyenAvian Influenza Group, The Pirbright Institute, Woking, United Kingdom.
Pengxiang ChangAvian Influenza Group, The Pirbright Institute, Woking, United Kingdom.
Joshua E SealyAvian Influenza Group, The Pirbright Institute, Woking, United Kingdom.
Sahar MahmoodAnimal and Plant Health Agency, Weybridge, United Kingdom.
Benjamin C MollettAnimal and Plant Health Agency, Weybridge, United Kingdom.
Marek J SlomkaAnimal and Plant Health Agency, Weybridge, United Kingdom.
Sharon M BrookesAnimal and Plant Health Agency, Weybridge, United Kingdom.
Munir IqbalAvian Influenza Group, The Pirbright Institute, Woking, United Kingdom.ORCID 0000-0001-5165-5339
Animal and Plant Health Agency · GBThe Pirbright Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L018853/1 and BB/S013792/1Biotechnology and Biological Sciences Research Council BB/N002571/1Biotechnology and Biological Sciences Research Council BB/R012679/1 BB/S013792/1 BBS/E/I/00007034 BBS/E/I/00007035Biotechnology and Biological Sciences Research Council BB/S011269/1Biotechnology and Biological Sciences Research Council BBS/E/I/00007034Biotechnology and Biological Sciences Research Council BBS/E/I/00007037
6 · The paper itself

Abstract

H9N2 avian influenza viruses (AIVs) have donated internal gene segments during the emergence of zoonotic AIVs, including H7N9. We used reverse genetics to generate A/Anhui/1/13 (H7N9) and three reassortant viruses (2:6 H7N9) which contained the hemagglutinin and neuraminidase from Anhui/13 (H7N9) and the six internal gene segments from H9N2 AIVs belonging to (i) G1 subgroup 2, (ii) G1 subgroup 3, or (iii) BJ94 lineages, enzootic in different regions throughout Asia. Infection of chickens with the 2:6 H7N9 containing G1-like H9N2 internal genes conferred attenuation

Indexed as

CoinfectionInfluenza A Virus, H7N9 SubtypeInfluenza A Virus, H9N2 SubtypeInfluenza, HumanInfluenza in BirdsAnimalsChickensHumansPhylogenyPoultryReassortant Virusesavian influenzachicken coinfectionH7N9H9N2internal genespoultryreassortmenttransmission

Identifiers

PMID36342296
PMCPMC9683025
OpenAlexW4308373610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.