Evidence map›Paper›PMID 36342170›Full record

ArticlemBio2022

Efficacy and Immune Correlates of OMP-1B and VirB2-4 Vaccines for Protection of Dogs from Tick Transmission of Ehrlichia chaffeensis.

Khemraj Budachetri, Mingqun Lin, Rory C Chien, Wenqing Zhang, Guy Nathaniel Brock, Yasuko Rikihisa

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Generation of Population-Level Diversity inPathogens (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Veterinary sciences · 2024
    Review
  6. Article
  7. Analysis ofbioRxiv : the preprint server for biology · 2024
    Article
  8. Review
  9. Analysis ofFrontiers in cellular and infection microbiology · 2024
    Article
  10. RipE expression correlates with high ATP levels inFrontiers in cellular and infection microbiology · 2024
    Article
  11. Antibody reactive immunomes ofFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Khemraj BudachetriDepartment of Veterinary Biosciences, College of Veterinary Medicine, Infectious Diseases Institute, Ohio State University, Columbus, Ohio, USA.
Mingqun LinDepartment of Veterinary Biosciences, College of Veterinary Medicine, Infectious Diseases Institute, Ohio State University, Columbus, Ohio, USA.
Rory C ChienDepartment of Veterinary Biosciences, College of Veterinary Medicine, Infectious Diseases Institute, Ohio State University, Columbus, Ohio, USA.
Wenqing ZhangDepartment of Veterinary Biosciences, College of Veterinary Medicine, Infectious Diseases Institute, Ohio State University, Columbus, Ohio, USA.
Guy Nathaniel BrockCenter for Biostatistics, Ohio State University, Columbus, Ohio, USA.
Yasuko RikihisaDepartment of Veterinary Biosciences, College of Veterinary Medicine, Infectious Diseases Institute, Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-1870-5338
The Ohio State University · US

Funding

Targeted Prevention of Human EhrlichiosisR01AI152223 · NIAID · OHIO STATE UNIVERSITY · PI RIKIHISA, YASUKO · 2021 to 2025
$2.0M
NIAID NIH HHS R01 AI152223
6 · The paper itself

Abstract

Ehrlichia chaffeensis, an obligatory intracellular bacterium, causes human monocytic ehrlichiosis, an emerging disease transmitted by the Lone Star tick, Amblyomma americanum. Here, we investigated the vaccine potential of OMP-1B and VirB2-4. Among the highly expressed and immunodominant

Indexed as

Ehrlichia chaffeensisEhrlichiosisTicksVaccinesAnimalsDogsHumansInterferon-gammaMiceInterferon-gammaVaccinesdogEhrlichiaIFN-γin-tick neutralizationISCOMOMP-1Btick transmissionvaccineVirB2-4

Identifiers

PMID36342170
PMCPMC9765013
OpenAlexW4308364459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.