Evidence map›Paper›PMID 36342130›Full record

ArticleApplied and environmental microbiology2022

GCN4 Enhances the Transcriptional Regulation of AreA by Interacting with SKO1 To Mediate Nitrogen Utilization in Ganoderma lucidum.

Lingdan Lian, Lingyan Shi, Jing Zhu, Liang Shi, Ang Ren, Hanshou You, Rui Liu, Mingwen Zhao

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. mBio · 2025
    Article
  3. The APSES transcription factor Swi6B upregulatesApplied and environmental microbiology · 2025
    Article
  4. Article
  5. The CBS/HCommunications biology · 2024
    Article
  6. Article
  7. A Gene fromJournal of fungi (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lingdan Lian *Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural Universitygrid.27871.3b, Jiangsu, Nanjing, People's Republic of China.
Lingyan Shi *Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural Universitygrid.27871.3b, Jiangsu, Nanjing, People's Republic of China.
Jing ZhuKey Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural Universitygrid.27871.3b, Jiangsu, Nanjing, People's Republic of China.
Liang ShiKey Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural Universitygrid.27871.3b, Jiangsu, Nanjing, People's Republic of China.
Ang RenKey Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural Universitygrid.27871.3b, Jiangsu, Nanjing, People's Republic of China.ORCID 0000-0002-8597-7755
Hanshou YouKey Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural Universitygrid.27871.3b, Jiangsu, Nanjing, People's Republic of China.
Rui LiuKey Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural Universitygrid.27871.3b, Jiangsu, Nanjing, People's Republic of China.
Mingwen ZhaoKey Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural Universitygrid.27871.3b, Jiangsu, Nanjing, People's Republic of China.ORCID 0000-0002-9413-1743
Nanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungi utilize a wide range of nitrogen to adapt their metabolism. The transcription factor GCN4 has a pivotal role in nitrogen metabolism. However, the mechanism by which GCN4 regulates nitrogen utilization in Ganoderma lucidum is not well understood. In this study, we found that GCN4 physically interacts with SKO1, a bZIP (basic leucine zipper) transcription factor. GCN4 cooperated with SKO1 to positively regulate nitrogen utilization, especially for the expression of

Indexed as

Fungal ProteinsReishiBasic-Leucine Zipper Transcription FactorsGene Expression Regulation, FungalNitrogenRepressor ProteinsTranscription FactorsBasic-Leucine Zipper Transcription FactorsFungal ProteinsNitrogenRepressor ProteinsTranscription FactorsAreAGanoderma lucidumGCN4nitrogen utilizationSKO1

Identifiers

PMID36342130
PMCPMC9680636
OpenAlexW4308371689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.