ReviewInternational journal for parasitology. Drugs and drug resistance2022
Anthelmintic resistance in equine nematodes: Current status and emerging trends.
Review in International journal for parasitology. Drugs and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited.International journal for parasitology. Drugs and drug resistance · 2023Pooled it
- Parasite management practices used by owners of Australian Pony Club horses and the factors influencing their decision-making processes.Australian veterinary journal · 2026Article
- Epidemiological study and risk factors of equine (Parasite epidemiology and control · 2026Article
- Enhanced detection of equine strongyles: Insights from morphological and nemabiome metabarcoding approaches in northern Iran.Equine veterinary journal · 2026Article
- Molecular Identification and Benzimidazole Resistance Analysis of Cyathostomins in Chinese Grazing Horses.Veterinary sciences · 2026Article
- Assessment of Knowledge, Attitudes, and Preventive Practices for Equine Endoparasite Control Among Livestock Owners in South Gondar Zone, Northwest Ethiopia.Veterinary medicine international · 2026Article
- Molecular surveillance and genetic diversity ofFrontiers in veterinary science · 2026Article
- Unusual Case of Simultaneous Vaginal and Rectal Prolapse in a Jennet: Clinical Presentation and Management.Case reports in veterinary medicine · 2026Article
- A Comparative Review of Donkey Genetic Resources, Production Traits, and Industrial Utilization: Perspectives from China and Globally.Animals : an open access journal from MDPI · 2025Review
- Reasons to be fearful? Rising proportions of positive faecal worm egg counts among UK horses (2007-2023).Equine veterinary journal · 2025Article
- Old world camels in Germany: parasitic nematode communities characterized by nemabiome analysis showed reduced anthelmintic efficacy according to the fecal egg count reduction test.Parasites & vectors · 2025Article
- Organoids in parasitology: a game-changer for studying host-nematode interactions.Parasitology · 2025Review
- In vitro culture of the parasitic stage larvae of hematophagous parasitic nematode Haemonchus contortus.International journal for parasitology · 2025Article
- The developmental lipidome of Nippostrongylus brasiliensis.Parasites & vectors · 2025Article
- Comparative assessment of Mini-FLOTAC, McMaster and semi-quantitative flotation for helminth egg examination in camel faeces.Parasites & vectors · 2025Article
- Combining in vivo and in vitro approaches to investigate the effect of sainfoin on strongyle infection, immunity, and large intestine ecosystem of horses.Journal of animal science · 2025Article
- Acquired immunity mechanisms in sheep infected withFrontiers in veterinary science · 2025Article
- Progress in serology and molecular biology of equine parasite diagnosis: sustainable control strategies.Frontiers in veterinary science · 2025Review
- Changes in equine strongylid communities after two decades of annual anthelmintic treatments at the farm level.Parasitology research · 2024Article
- Deciphering Chemical Rules for Drug Penetration into Strongyloides.Pharmaceutics · 2024Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anthelmintic resistance is reported in equine nematodes with increasing frequency in recent years, and no new anthelmintic classes have been introduced during the past 40 years. This manuscript reviews published literature describing anthelmintic resistance in cyathostomins, Parascaris spp., and Oxyuris equi with special emphasis on larvicidal efficacy against encysted cyathostomin larvae and strongylid egg reappearance periods (ERP). Resistance to benzimidazoles and pyrimidines is highly prevalent in cyathostomin populations around the world, and macrocyclic lactone resistance has been documented in cyathostomins in recent years as well. Two recent studies have documented resistance to the larvicidal regimen of fenbendazole, whereas the larvicidal efficacy of moxidectin is variable, but with no evidence of a reduction from historic levels. In the 1990s, ERP estimates were 8-10 and 12-16 weeks for ivermectin and moxidectin, respectively, while several studies published after year 2000 found ERPs to be 5 weeks for both compounds. This is a clear change in anthelmintic performance, but it remains unclear if this is due to development of anthelmintic resistance or selection for other biological traits leading to a quicker resumption of strongylid egg shedding following anthelmintic treatment. Macrocyclic lactone resistance is common in Parascaris spp. around the world, but recent reports suggests that resistance to the two other classes should be monitored as well. Finally, O. equi has been reported resistant to ivermectin and moxidectin in countries representing four continents. In conclusion, multi-drug resistance is becoming the norm in managed cyathostomin populations around the world, and a similar pattern may be emerging in Parascaris spp. More work is required to understand the mechanisms behind the shortened ERPs, and researchers and veterinarians around the world are encouraged to routinely monitor anthelmintic efficacy against equine nematodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.