Evidence map›Paper›PMID 36341886›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids2022

Radiosynthesis of 20-[

Juno Van Valkenburgh, Marlon Vincent V Duro, Erica Burnham, Quan Chen, Shaowei Wang, Jenny Tran, Bilal E Kerman, Sung Hee Hwang, Xiaodan Liu, Naomi S Sta Maria and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  2. Highlights on U.S. FDA-approved halogen-containing drugs in 2024.European journal of medicinal chemistry · 2025
    Review
  3. Review
  4. Synthesis and Preclinical Evaluation of 22-[ACS chemical neuroscience · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Juno Van ValkenburghDepartment of Radiology, Keck School of Medicine University of Southern California, Los Angeles, CA 90033, United States of America.
Marlon Vincent V DuroDepartment of Radiology, Keck School of Medicine University of Southern California, Los Angeles, CA 90033, United States of America.
Erica BurnhamDepartment of Medicine, Keck School of Medicine University of Southern California, Los Angeles 90033, CA, United States of America.
Quan ChenDepartment of Radiology, Keck School of Medicine University of Southern California, Los Angeles, CA 90033, United States of America.
Shaowei WangDepartment of Medicine, Keck School of Medicine University of Southern California, Los Angeles 90033, CA, United States of America.
Jenny TranDepartment of Medicine, Keck School of Medicine University of Southern California, Los Angeles 90033, CA, United States of America.
Bilal E KermanDepartment of Medicine, Keck School of Medicine University of Southern California, Los Angeles 90033, CA, United States of America.
Sung Hee HwangDepartment of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California, Davis, CA 95616, United States of America.
Xiaodan LiuZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.
Naomi S Sta MariaZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.
Francesca ZanderigoDepartment of Psychiatry, Columbia University, New York, NY 10032, United States of America; Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY 10032, United States of America.
Etienne CroteauResearch Center on Aging, Department of Medicine, University of Sherbrooke, Sherbrooke, QC J1H 4C4, Canada.
Stanley I RapoportNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, United States of America.
Stephen C CunnaneResearch Center on Aging, Department of Medicine, University of Sherbrooke, Sherbrooke, QC J1H 4C4, Canada.
Russell E JacobsZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.
Hussein N YassineDepartment of Medicine, Keck School of Medicine University of Southern California, Los Angeles 90033, CA, United States of America. Electronic address: hyassine@usc.edu.
Kai ChenDepartment of Radiology, Keck School of Medicine University of Southern California, Los Angeles, CA 90033, United States of America. Electronic address: chenkai@med.usc.edu.
University of Southern California · USUniversité de Sherbrooke · CANational Institute on Alcohol Abuse and Alcoholism · USNew York Psychoanalytic Society and Institute · USUC Davis Comprehensive Cancer Center

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The delivery of essential fatty acids to the Brain in Alzheimer's diseaseR01AG054434 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$5.4M
Biomarkers of ABCA1 mediated functions in Alzheimers diseaseR01AG055770 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$4.2M
Effect of diabetes and AD pathology on brain imaging and cognition in Latino adultsRF1AG078362 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BORZAGE, MATTHEW, BRASKIE, MEREDITH NICOLE · 2022 to 2022
$3.8M
ApoE, ABCA1 and endosomal dysregulation in ADR01AG067063 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2020 to 2024
$3.4M
Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4 Diversity SupplementRF1AG076124 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARVANITAKIS, ZOE, YASSINE, HUSSEIN N · 2022 to 2024
$2.5M
DHA brain delivery by APOE genotypeR21AG056518 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2018 to 2019
$464k
A Symposium on Nutrition State of Science for Dementia PreventionR13AG069386 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2020 to 2020
$50k
NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG054434NIA NIH HHS R01 AG055770NIA NIH HHS R01 AG067063NIA NIH HHS R13 AG069386NIA NIH HHS R21 AG056518NIA NIH HHS RF1 AG076124NIA NIH HHS RF1 AG078362
6 · The paper itself

Abstract

Dysreglulated brain arachidonic acid (AA) metabolism is involved in chronic inflammation and is influenced by apolipoprotein E4 (APOE4) genotype, the strongest genetic risk factor of late-onset Alzheimer's disease (AD). Visualization of AA uptake and distribution in the brain can offer insight into neuroinflammation and AD pathogenesis. Here we present a novel synthesis and radiosynthesis of 20-[

Indexed as

Alzheimer DiseaseApolipoprotein E4AnimalsAstrocytesBrainHumansMagnetic Resonance ImagingMiceMice, TransgenicPositron-Emission TomographyApolipoprotein E4ApoE4Arachidonic acidBrain imagingFatty acidPET-MR

Identifiers

PMID36341886
PMCPMC9888757
OpenAlexW4306953703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.