ArticleThe EMBO journal2022
An accessory prefrontal cortex-thalamus circuit sculpts maternal behavior in virgin female mice.
Article in The EMBO journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Traces of Parenthood but Not Pregnancy Loss in UK Biobank Structural Brain MRI Data.Human brain mapping · 2026Article
- Experience-dependent maternal defense behavior mediated by profrontal cortical projections to the medial preoptic area in mice.Nature communications · 2025Article
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Article
- Dense 4D nanoscale reconstruction of living brain tissue.Nature methods · 2023Article
- Interaction of the pre- and postnatal environment in the maternal immune activation model.Discover mental health · 2023Review
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Authors and funding
7 authors.
Funding
Abstract
The ability to care for the young is innate and readily displayed by postpartum females after delivery to ensure offspring survival. Upon pup exposure, rodent virgin (nulliparous) females also develop parental behavior that over time becomes displayed at levels equivalent to parenting mothers. Although maternal behavior in postpartum females and the associated neurocircuits are well characterized, the neural mechanisms underlying the acquisition of maternal behavior without prior experience remain poorly understood. Here, we show that the development of maternal care behavior in response to first-time pup exposure in virgin females is initiated by the activation of the anterior cingulate cortex (ACC). ACC activity is dependent on feedback excitation by Vglut2
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