Evidence map›Paper›PMID 36341443›Full record

ArticleFrontiers in immunology2022

Case report:

Tina Trachsel, Seraina Prader, Katharina Steindl, Jana Pachlopnik Schmid

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tina TrachselDivision of Immunology, University Children's Hospital Zurich, Zurich, Switzerland.
Seraina PraderDivision of Immunology, University Children's Hospital Zurich, Zurich, Switzerland.
Katharina SteindlInstitute of Medical Genetics, University of Zurich, Schlieren, Switzerland.
Jana Pachlopnik SchmidDivision of Immunology, University Children's Hospital Zurich, Zurich, Switzerland.
University Children's Hospital Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Jacobsen syndrome is a rare genetic disorder associated with a terminal deletion in chromosome 11. The clinical presentation is variable. Although immunodeficiency has been described in patients with Jacobsen syndrome, a clear genotype-phenotype correlation has not yet been established. Here, we report on the immunologic phenotypes of four patients with Jacobsen syndrome. All four patients showed one or more atypical immunologic features. One patient suffered from recurrent viral infections, two patients had experienced a severe bacterial infection and one had received antibiotic prophylaxis since early childhood. One patient had experienced severe, transient immune dysregulation. Hypogammaglobulinemia and low B cell counts were found in two patients, while the number of recent thymic emigrants (CD31+CD45RA+ CD4 cells) was abnormally low in three. When considering the six immune-related genes located within the affected part of chromosome 11 (

Indexed as

Jacobsen Distal 11q Deletion SyndromeChild, PreschoolDNA-Binding ProteinsGene DeletionHumansPhenotypeProto-Oncogene Protein c-ets-1Thymus GlandT-LymphocytesDNA-Binding ProteinsETS1 protein, humanNFRKB protein, humanProto-Oncogene Protein c-ets-1ETS1genetic disorderimmunodeficiencyJacobsen syndromerecent thymic emigrants

Identifiers

PMID36341443
PMCPMC9634179
OpenAlexW4306969887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.